Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response

ABSTRACT: Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response

PROVIDER: PRJNA1214822 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response

Project description:Effector-triggered immunity (ETI) is a form of pathogen sensing that involves detection of pathogen-encoded virulence factors or “effectors”. To discover novel ETI pathways in mammals, we developed a screening approach in which individual virulence factors are expressed in human monocytes and transcriptional responses are assessed by RNA-seq. Using this approach, we identify a poxvirus effector, myxoma virus M3.1, which elicits an anti-viral NF-κB response. We find that NF-κB is unleashed by an ETI pathway that senses M3.1 attack of two anti-viral complexes: ZAP and TBK1. NF-κΒ activation occurs because the proteins inhibited by M3.1—N4BP1, ZC3H12A, and TBK1—are negative regulators of NF-κB. Our results illustrate how negative regulators can function as pathogen sensors and establish a systematic approach for the discovery of ETI pathways.

2025-02-16 | GSE287860 | GEO

Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response [RNAseq_2]

Project description:Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response [RNAseq_2]

| PRJNA1215430 | ENA

Poxvirus attack of anti-viral defense pathways unleashes an effector-triggered NF-κB response [RNAseq_2]

2025-02-16 | GSE288000 | GEO

MinION poxvirus seq

Project description:MinION poxvirus seq

| PRJEB8656 | ENA

Wadden Sea poxvirus

Project description:Wadden Sea poxvirus Genome sequencing and assembly

| PRJNA896524 | ENA

short and long attack latency mice

Project description:Two wild house mice lines were genetically selected for short and long attack latency. Mice with an attack latency <50s or >600s were considered short attack latency mice (SAL) and long attack latency mice(LAL) respectively. RNA from the hippocampus of 14 SAL or 14 LAL mice was pooled and used as input material for the SAGE libraries. Keywords: other

2003-10-31 | GSE786 | GEO

short and long attack latency mice

2003-10-30 | E-GEOD-786 | biostudies-arrayexpress

Salmon gill poxvirus genome survey

Project description:Salmon gill poxvirus virus genome survey

| PRJEB47286 | ENA

Interplay between MAMPs-triggered and SA-mediated defense responses

Project description:The Arabidopsis Pathoarray 464_001 (GPL3638) was used to compare response of Col-0, pad4-1 (Zhou et al., 1998; Jirage et al., 1999) and sid2-2 (Wildermuth et al., 2001) to Pseudomonas syringae pv. tomato DC3000 hrcC mutant. SA production is drastically reduced in sid2 mutants. PAD4 is required for SA-mediated responses. The results suggested that the SA increase triggered by MAMPs is one major component in the MAMPs-triggered signaling mechanism. Keywords: Responses of Arabidopsis to Pseudomonas syringae pv. tomato DC3000 hrcC mutant

2007-07-14 | GSE8273 | GEO

Host-responses to Poxvirus-infected macrophages

Project description:Host-responses to Poxvirus-infected macrophages

| PRJNA494077 | ENA