Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Developmental toxicity of new psychoactive substance esketamine to zebrafish

PROVIDER: PRJNA1214993 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32105502_1.fastq.gz	Fastqsanger.gz
	SRR32105502_2.fastq.gz	Fastqsanger.gz
	SRR32105503_1.fastq.gz	Fastqsanger.gz
	SRR32105503_2.fastq.gz	Fastqsanger.gz
	SRR32105504_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Elucidating mechanisms of perfluorobutanoic acid (PFBA) exposure in larval zebrafish (Danio rerio).

Project description:Perfluorobutanoic acid (PFBA) is a short-chain polyfluoroalkyl substance (PFAS) that is measurable in fish tissues and environmental matrices. Previous studies suggest that there are adverse effects on animal and human health following exposure to PFBA, however the mechanisms underlying the toxicity are not well characterized. This study measured biological responses (developmental, transcriptome, and behavioral responses) of zebrafish (wild-type AB strain, Danio rerio) following exposure to a range of PFBA concentrations (0.1-100 µl/L). To further elucidate putative mechanisms related to locomotor abnormalities by PFBA, RNA-seq was conducted. These data shed new mechanistic light onto the sublethal effects of lesser studied short chain perfluorinated chemicals.

2025-08-31 | GSE291250 | GEO

Quantitative profiling of proteome extracted from zebrafish embryos exposed to different concentrations of the fungicide difenoconazole against untreated control groups.

Project description:In the present study OMICs analysis was employed to investigate the early molecular responses of zebrafish embryos to exposure to the fungicide difenoconazole. Difenoconazole, a sterol biosynthesis inhibitor according to Fungicide Resistance Action Committee (FRAC) classification, may also induce adverse effects on non-target organisms inhabiting the environment. Early molecular responses in terms of transcriptome and proteome analysis were investigated and refined to select potentially substance specific biomarker candidates for early prediction of difenoconazole toxicity in zebrafish embryos.

2024-01-02 | PXD045650 | Pride

Quantitative profiling of proteome extracted from zebrafish embryos exposed to different concentrations of the fungicide metalaxyl against untreated control groups.

Project description:In the present study OMICs analysis was employed to investigate the early molecular responses of zebrafish embryos to exposure to the fungicide metalaxyl. Metalaxyl, a nucleic acid metabolism inhibitor according to Fungicide Resistance Action Committee (FRAC) classification, may also induce adverse effects on non-target organisms inhabiting the environment. Early molecular responses in terms of transcriptome and proteome analysis were investigated and refined to select potentially substance specific biomarker candidates for early prediction of metalaxyl toxicity in zebrafish embryos.

2024-01-02 | PXD045444 | Pride

DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina

Project description:Intestinal helminths cause iron-deficiency anemia in pregnant women, associated with premature delivery, low birth weight, maternal ill health, and maternal death. Although benzimidazole compounds such as mebendazole (MBZ) are highly efficacious against helminths, there are limited data on its use during pregnancy. In this study, we performed in vivo imaging of the retinas of zebrafish larvae exposed to MBZ, and found that exposure to MBZ during 2 and 3 days post-fertilization caused malformation of the retinal layers. To identify the molecular mechanism underlying the developmental toxicity of MBZ, we performed transcriptome analysis of zebrafish eyes. The analysis revealed that the DNA damage response was involved in the developmental toxicity of MBZ. We were also able to demonstrate that inhibition of ATM significantly attenuated the apoptosis induced by MBZ in the zebrafish retina. These results suggest that MBZ causes developmental toxicity in the zebrafish retina at least partly by activating the DNA damage response, including ATM signaling, providing a potential adverse outcome pathway in the developmental toxicity of MBZ in mammals.

2016-03-24 | GSE75245 | GEO

Expression data from human myocardial cells, AC16

Project description:This study aimed to provide new compelling clues in the PM2.5-induced toxicity and mechanism which order the meaningful bioinformatics evidences for further study on human cardiovascular system. We used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of up-regulated genes after treated with chemical substance

2019-12-05 | GSE141418 | GEO

Expression data from human myocardial cells, AC16

Project description:This study aimed to provide new compelling clues in the PM2.5-induced toxicity and mechanism which order the meaningful bioinformatics evidences for further study on human cardiovascular system. We used microarrays to detail the global program of gene expression underlying cellularisation and identified distinct classes of up-regulated genes after treated with chemical substance.

2017-03-01 | GSE95506 | GEO

Lurasidone Induces Developmental Toxicity and Behavioral Impairments in Zebrafish Embryos

Project description:Lurasidone Induces Developmental Toxicity and Behavioral Impairments in Zebrafish Embryos

| PRJNA1277809 | ENA

Project description:Transcriptomic analysis of the developmental toxicity of microplastics in zebrafish

| PRJNA666534 | ENA

Transcriptomic alterations of thallium-exposed zebrafish embryos

Project description:Thallium (Tl) is a trace metal element used in the electronics, semiconductor and electro-optical industries. With the development of high-tech industries, thallium severely pollutes the aquatic environment. The purpose of this study was to evaluate the cardiotoxicity and developmental toxicity of Tl by using vertebrate model zebrafish embryos. RNA-seq was performed on wild type zebrafish embryos exposed to 0, 200, and 800 ppb Tl from 6 to 48 hpf. The transcriptomic profile revealed molecular understanding regarding the cardiovascular and developmental toxicity of Tl, providing valuable information for risk assessment of the emerging contaminant thallium.

2022-09-21 | GSE213589 | GEO

Expression data from zebrafish embryos

Project description:Zebrafish embryos are sensitive to chemical substance and often used as a in vivo model for enviromental toxicology research. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes after treated with chemical substance

2016-12-06 | GSE90875 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data