Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TNBC organoid sc-multiome seq data treated with epigenetic drugs

ABSTRACT: TNBC organoid sc-multiome seq data treated with epigenetic drugs

PROVIDER: PRJNA1219492 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

TNBC organoid sc-multiome seq data treated with epigenetic drugs

Project description:Identifying biologically relevant signals from single-cell omics data to ultimately promote precision medicine is one current grant challenge. To address this challenge, we focused on triple-negative breast cancer (TNBC), integrated bulk and single-cell RNA-seq data from a large global population, and identified subpopulation identities that were able to provide responsive trajectories upon treatment. As a proof of principle, we applied our computational frame work on a TNBC organoid treated with two epigenetic drugs, JQ1 and MS177. We used this model to highlight how different components within the tumor responded molecularly differently to drug treatment.

2025-02-06 | GSE288798 | GEO

Multiome experiment of the neuroepithelial stage of brain organoid developement

Project description:To investigate the heterogeneity during the neuroepithelial stage of organoid development, we performed a multiome experiment on day 15-18 old brain organoids

2022-10-03 | E-MTAB-12004 | biostudies-arrayexpress

GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid SC

Project description:GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders Organoid SC

2024-06-27 | E-MTAB-13478 | biostudies-arrayexpress

Multiome experiment from GLI3 KO brain organoids

Project description:To study the effect of GLI3 knockout on early brain organoid development, we collected single-cell multiome data from 18 day old brain organoids

2022-08-25 | E-MTAB-12002 | biostudies-arrayexpress

Multiome experiment of the neuroepithelial stage of brain organoid developement

Project description:Multiome experiment of the neuroepithelial stage of brain organoid developement

| PRJEB55237 | ENA

Investigate how Sox9 overexpression influences ATII lineage plasticity by sc-multiome

Project description:Investigate how Sox9 overexpression influences ATII lineage plasticity by sc-multiome

| PRJNA1135134 | ENA

sc-lineage TNBC MDA-MB-231

Project description:Single-cell transcriptional lineage tracing TNBC MDA-MB-231

| PRJEB53139 | ENA

Spatially resolved multiomics of human cardiac niches - Multiome GEX

Project description:Using Multiome and previously published sc/snRNA-seq data, we studied eight anatomical regions of the human heart including left and right ventricular free walls (LV and RV), left and right atria (LA and RA), left ventricular apex (AX), interventricular septum (SP), sino-atrial node (SAN) and atrioventricular node (AVN). For the first time, we profile the cells of the human cardiac conduction system, revealing their distinctive repertoire of ion channels, G-protein coupled receptors and cell-cell interactions. We map the identified cells to spatial transcriptomic data to discover cellular niches within the eight regions of the heart.

2023-06-13 | E-MTAB-12916 | biostudies-arrayexpress

Spatially resolved multiomics of human cardiac niches - Multiome ATAC

2023-06-13 | E-MTAB-12919 | biostudies-arrayexpress

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet_snATAC]

Project description:Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet_snATAC]

| PRJNA836326 | ENA