Project description:Analysis of proteomic consequences of Tyrobp deletion in a Huntington's disease mouse model. Examination of protein expression alterations in the striatum of mutant huntingtin-Q175 with and without TYROBP (protein tyrosine kinase-binding protein).

2022-01-05 | MSV000088643 | MassIVE

CMS121 partially attenuates disease progression in mouse models of Huntington's disease

Project description:To investigate the effects of the drug candidate CMS121 on transcrptional changes in the striatum of the R6/2 mouse model of Huntington's disease at 14 weeks of age.

2024-06-26 | GSE223847 | GEO

Project description:Small RNA sequencing of striatum samples of the Huntington's disease mice model BACHD

| PRJNA686706 | ENA

Gene expression profiling of striatum in Huntington's disease model mouse

Project description:Gene expression profiling of striatum in Huntington's disease model mouse

| PRJNA454481 | ENA

Targeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)

Project description:Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3K4 demethylase SMCX/Jarid1c in primary neurons reversed down-regulation of key neuronal genes caused by mutant Huntingtin (Htt) expression. Finally, reduction of SMCX/Jarid1c in primary neurons from BACHD mice or the single Jarid1 in a Drosophila HD model was protective. Therefore, targeting this epigenetic signature may be an effective strategy to ameliorate the consequences of HD. ChIP-seq for H3K4me3 in wild type and R6/2 cortex and striatum at 8 and 12 weeks.

2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress

Modeling endogenous HTT/mHTT pathogenesis in fibroblasts and striatal GABAergic neurons from a Mongolian family with Huntington’s disease

Project description:Single cell RNA-seq and bulk RNA-seq characterization of human induced pluripotent stem cell (hiPSCs) derived Huntington's disease organoids resembling the human striatum

2022-02-26 | GSE184255 | GEO

CSF1R inhibitor-mediated microglial depletion prevents reductions in striatal volume, extracellular matrix alterations, and perineuronal net loss in a mouse model of Huntington’s disease

Project description:This dataset allows for the exploration of gene expression of microdissected striatum from 11 week old wild-type and the R6/2 mouse model of Huntington's disease, in the presence or absence of microglia. Microglia were depleted via dietary administration of the CSF1R inhibitor PLX3397 from 6 to 11 weeks of age.

2019-08-22 | GSE136158 | GEO