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Extracorporeal shock waves effectively suppress colorectal cancer proliferation and growth

ABSTRACT: Extracorporeal shock waves effectively suppress colorectal cancer proliferation and growth

PROVIDER: PRJNA1227473 | ENA |

REPOSITORIES: ENA

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Extracorporeal shock waves effectively suppress colorectal cancer proliferation and growth

Project description:Shock waves are widely used to treat various diseases and have numerous medical applications. In particular, extracorporeal shock waves (ESV) can substantially inhibit tumour growth. However, the therapeutic efficacy of ESV in colorectal cancer and its underlying mechanisms are not well understood. To address this gap in our knowledge, colorectal cancer cell lines HT29 and SW620 were used to generate xenograft mouse models and examined the therapeutic effects of a stepwise increase in ESV energy on tumour growth. In vivo, 60 mJ ESV significantly delayed xenograft growth compared with 120 and 240 mJ ESV, with no impact on body weight or hepatic and renal function. Transcriptome analysis revealed that 60 mJ ESV suppressed colorectal cancer cell proliferation and induced apoptosis and ferroptosis; these findings were further confirmed by immunohistochemical staining and western blotting. The in vitro study showed that ESV mechanistically suppressed cell proliferation and induced apoptosis and ferroptosis by activating the p53 signaling pathway. In conclusion, 60 mJ ESV substantially inhibited colorectal cancer growth by activating p53 pathway-related proliferation inhibition and cell death. These findings indicate that ESV therapy is a promising therapeutic strategy for colorectal cancer.

2025-02-25 | GSE290314 | GEO

Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

Project description:Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

| PRJNA757005 | ENA

Gene Expression of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

Project description:Gene Expression of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

| PRJNA756995 | ENA

DNA Methylation of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

Project description:DNA Methylation of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

| PRJNA757006 | ENA

Transciptomic signature of chronic antibody-mediated kidney rejection traited by extracorporeal photopheresis

Project description:Background: The benefit of extracorporeal photopheresis on the course of kidney transplant rejection is unknown. The aim of our study was to investigate the variations in transcriptomics on graft biopsies when extracorporeal photopheresis was used to treat chronic humoral rejection after kidney transplantation. Methods: we retrospectively analyzed the mRNA expression of 770 genes of interest in graft biopsies performed before and after treatment. Eight patients received an average of 23 extracorporeal photopheresis sessions over 4 months between the two biopsies. Results: Transcriptomic analysis of the graft biopsies identified a significant (adjusted p-value< 0.05) increase in CAV1 mRNA in all patients and a significant decrease in CD19, IL21, PAX5, and SFTPA2 mRNAs in 7 of 8 patients. Conclusions: In patients treated with extracorporeal photopheresis for chronic humoral rejection after renal transplantation, omic analysis of repeated biopsies shows a reduction in fibrotic and inflammatory transcriptomic signatures.

2024-02-28 | GSE240778 | GEO

Molecular Prognosis of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

Project description:Prognosis for cardiogenic shock patients under ECMO was our study goal. Success defined as survived more than 7 days after ECMO installation and failure died or had multiple organ failure in 7 days. Total 34 cases were enrolled, 17 success and 17 failure. Peripheral blood mononuclear cells collected at ECMO installation were used analyzed.

2019-12-31 | GSE93101 | GEO

DNA Methylation of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

2024-10-15 | GSE182608 | GEO

Gene Expression of Cardiogenic Shock Patients under Extracorporeal Membrane Oxygenation

2024-10-15 | GSE182600 | GEO

Effect of Extracorporeal Shock Waves on Induced Neocollagenesis of Integumentary Tissue

Project description:Background Obesity became a worldwide public health problem and its treatment presents a strict relationship with skin flaccidity, for which the development of non-invasive therapies is an emerging field. Objective This study aims to evaluate the physiological response of the skin tissue of individuals with obesity with flaccidity to the physiological stimulus of shockwave therapy (ESWT). Methods This is a comparative intervention study based on histological and immunohistochemical analyses of a set of samples of skin tissue of women with Grade II obesity who achieved a 10 percent preoperative weight loss before bariatric surgery and complaints of skin flaccidity, subjected to the ESWT treatment. A total of seven sessions were carried out in the abdominal region on the left side, and the collateral side was used as control; the biological material was collected at the moment of the bariatric surgery. Hematoxylin and Eosin, Masson’s trichrome, Picrosirius Red and the markers for immunohistochemical were used for the morphological evaluation. Results Fourteen women were included in the research. The results demonstrated that the tissue which underwent the ESWT intervention presented significant increases of fibroblast cells (p<0.0001) and collagen fibers Type I and II (p<0.0002). In the significant expressions of the markers FGF1, FGF2, FGFR1 were identified in the exposed side (p<0.0002, 0.0017, <0.0001, respectively) as well as a significantly higher expression of Ki67 marker of cell proliferation (p<0.0002). Conclusion ESWT was associated with a significant increase of cell proliferation and collagen expression in flaccid skin of individuals who achieved weight loss before bariatric surgery.

| S-EPMC9586529 | biostudies-literature

Shock waves induce an evolutionary conserved mechanism of spinal cord regeneration via Toll-like receptor 3

Project description:Shock waves induce an evolutionary conserved mechanism of spinal cord regeneration via Toll-like receptor 3

| PRJNA628694 | ENA