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Mesomycoplasma hyopneumoniae

ABSTRACT: Causes enzootic pneumonia in swine

PROVIDER: PRJNA12343 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	MWWN01.dat.gz	Other
	MWWN01.fasta.gz	Fasta.gz
	MWWN01.master.dat	Other
	NBBN01.dat.gz	Other

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Mesomycoplasma hyopneumoniae 7448

Project description:Causative agent of enzootic pneumonia in swine.

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Mesomycoplasma hyopneumoniae J strain:J

Project description:Causative agent of enzootic pneumonia in swine.

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Global Transcriptional Analysis of Mycoplasma hyopneumoniae Following Exposure to Hydrogen Peroxide

Project description:Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia, colonizes the cilia of swine lungs, causing ciliostasis and cell death. Mycoplasma hyopneumoniae is a component of the porcine respiratory disease complex (PRDC) and is especially problematic for the finishing swine industry, causing the loss of hundreds of millions of dollars in farm revenues worldwide. For successful infection, M. hyopneumoniae must effectively resist oxidative stresses due to the release of oxidative compounds from neutrophils and macrophages during the host’s immune response. However, the mechanism M. hyopneumoniae uses to avert the host response is still unclear. To gain a better understanding of the transcriptional responses of M. hyopneumoniae under oxidative stress, cultures were grown to early exponential phase and exposed to 0.5% percent hydrogen peroxide for 15 minutes. RNA samples from these cultures were collected and compared to RNA samples from control cultures using two-color PCR-based M. hyopneumoniae microarrays. This study revealed significant down-regulation of important glycolytic pathway genes and gene transcription proteins, as well as a protein known to activate oxidative stressor cascades in neutrophils. This study has also contained significantly differentially expressed genes common to other environmental stress responses, and merits further study of universal stress response genes of M. hyopneumoniae. Keywords: Mycoplasma hyopneumoniae, RNA microarray

2007-11-01 | GSE8304 | GEO

Mesomycoplasma hyopneumoniae 232

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Differential responses to stress of two Mycoplasma hyopneumoniae strains

Project description:Mycoplasma hyopneumoniae pathogenic strains, like 7448, are the causative agents of porcine enzootic pneumonia. Non-pathogenic strains, like M. hyopneumoniae J, does not cause disease, although shares the entire repertoire of known virulence-related genes with M. hyopneumoniae 7448. In this context, the differential expression of ortholog genes is likely responsible, at least in part, for differences in pathogenicity or virulence level between these strains. Moreover, in the porcine lung, M. hyopneumoniae faces a hostile environment, with both oxidative and heat stresses. The performed comparative proteomics analyses provided evidence of differential stress responses between a pathogenic and a non-pathogenic M. hyopneumoniae strain, involving tens of proteins, including some known virulence factors. The results suggest that stress conditions trigger the expression of potential virulence factors in the pathogenic M. hyopneumoniae 7448, but not in the non-pathogenic M. hyopneumoniae J.

2019-03-29 | PXD012742 | Pride

Mesomycoplasma hyopneumoniae

Project description:Transcriptome Changes in Mycoplasma hyopneumoniae During Infection

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Project description:Mesomycoplasma hyopneumoniae Genome sequencing

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