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Distinct molecular mechanisms of stress habituation in the mouse hippocampus [bulk ATAC-seq]

ABSTRACT: Distinct molecular mechanisms of stress habituation in the mouse hippocampus [bulk ATAC-seq]

PROVIDER: PRJNA1237685 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32763600_1.fastq.gz	Fastqsanger.gz
	SRR32763600_2.fastq.gz	Fastqsanger.gz
	SRR32763601_1.fastq.gz	Fastqsanger.gz
	SRR32763601_2.fastq.gz	Fastqsanger.gz
	SRR32763602_1.fastq.gz	Fastqsanger.gz

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Distinct molecular mechanisms of stress habituation in the mouse hippocampus [bulk RNA-seq]

Project description:We explore how the tightly regulated molecular response triggered by acute restraint stress becomes altered after repeated restraint exposure. Transcriptomic sampling of the mouse hippocampus at multiple time points revealed that repeated stress leads to widespread habituation, damping stress-induced gene expression of all stress-responsive genes. However, we find no evidence for the emergence of new response profiles or alterations in baseline gene expression. Using single-cell multi-omics, we show that these findings hold true across cell types, and we reveal cell type specific patterns of habituation. Transcriptomic and chromatin accessibility profiles identify two distinct mechanisms that contribute to the observed habituation patterns: an early cAMP-associated mechanism that is related to blunted transcription after chronic stress, and a late corticosterone-dependent mechanism that is linked to a shortened transcriptional response.

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Aplysia Pleural Ganglia 24 Hours After Long-Term Habituation Training

Project description:We used a custom-designed microarray and qPCR to characterize the persistent transcriptional response to long-term habituation training in the marine mollusk Aplysia californica. Aplysia were exposed to either 3 days of spaced long-term habituation training (10 rounds of stimulation/day; each round = 15 min brushing at a 10s ISI; 15 min rest between rounds); a matched set of controls was not exposed to any brushing (n = 8/group). While reflex responsiveness remained stable in controls, trained animals exhibited a large reduction in siphon-withdrawal duration that was evident at stimulation sites across the entire dorsal surface of the body (head, tail, and siphon). This habituation was retained for at least 24 hours after the end of training. Immediately after 24 hour retention tests, pleural ganglia were harvested from each trained animal and its matched control. The pleural ganglia contain the VC nociceptors, which we confirmed are activated by the brush stimulus used to produce habituation. Microarray analysis from 8 biological replicates suggests that long-term habituation training persistently regulates 21 transcripts. We used qPCR to test a subset of these transcripts and found persistent regulation of an putative Aplysia cornichon homolog.

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