Human Virome
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1240015 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Viromics Study of 421 Serum Samples (Single Samples, Non-Pooled)
| PRJNA1240012 | ENA
Project description:Metagenomic Virome Study of Sputum Samples from 291 Children with Pneumonia
| PRJNA1240018 | ENA
Project description:Metagenomic Virome Study of Cerebrospinal Fluid Samples from 152 Children with Encephalitis
| PRJNA1240017 | ENA
Project description:A Comparative Viromics Study of 1,236 Plasma and PBMC Samples
| PRJNA1240010 | ENA
Project description:A Comparative Viromics Study of Paired Plasma and PBMC Samples from 1,896 Healthy Individuals
| PRJNA1240009 | ENA
Project description:<p>The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of the cervicovaginal metabolome in two independent pregnancy cohorts (VMET, n = 160; 455 swabs; VMET II, n = 205; 573 swabs). By integrating metataxonomics and immune profiling data from matched samples, we show that specific metabolome signatures can be used to robustly predict simultaneously both the composition of the vaginal microbiome and host inflammatory status. In these patients, vaginal microbiota instability and innate immune activation, as predicted using DESI-MS, associated with preterm birth, including in women receiving cervical cerclage for preterm birth prevention. These findings highlight direct on-swab metabolic profiling by DESI-MS as an innovative approach for preterm birth risk stratification through rapid assessment of vaginal microbiota-host dynamics.</p><p><br></p><p><strong>Linked cross omic data sets:</strong></p><p>Meta-taxonomics data associated with this study are available in the European Nucleotide Archive (ENA): accession number <a href='https://www.ebi.ac.uk/ena/browser/view/PRJEB11895' rel='noopener noreferrer' target='_blank'>PRJEB11895</a>, <a href='https://www.ebi.ac.uk/ena/browser/view/PRJEB12577' rel='noopener noreferrer' target='_blank'>PRJEB12577</a> and <a href='https://www.ebi.ac.uk/ena/browser/view/PRJEB41427' rel='noopener noreferrer' target='_blank'>PRJEB41427</a>.</p>
2021-09-23 | MTBLS717 | MetaboLights
Project description:Metagenomic Sequencing Samples of Throat Swabs from 64 Patients with Unexplained Fever
| PRJNA1240019 | ENA
Project description:Metagenomic Sequencing Samples of Throat Swabs from 72 Patients with Unexplained Fever
| PRJNA1240020 | ENA
Project description:Metagenomic Sequencing Samples of Throat Swabs from 81 Influenza-Like Illness Patients
| PRJNA1240021 | ENA
Project description:Viromics Study of Serum Samples from 214 Febrile Patients, Pooled into 54 Pools
| PRJNA1240014 | ENA