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CD177+ neutrophils to restrict neuroinflammation following CNS injury

ABSTRACT: CD177+ neutrophils to restrict neuroinflammation following CNS injury

PROVIDER: PRJNA1242790 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32895825_1.fastq.gz	Fastqsanger.gz
	SRR32895825_2.fastq.gz	Fastqsanger.gz
	SRR32895826_1.fastq.gz	Fastqsanger.gz
	SRR32895826_2.fastq.gz	Fastqsanger.gz

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CD177+ neutrophils to restrict neuroinflammation following CNS injury

Project description:Neutrophils are the most abundant circulating leukocyte population that play critical roles in neuroinflammation after ischemic stroke. CD177, a glycoprotein on neutrophils, is emerging as an important immune regulator which fundamentally affects multiple inflammatory diseases. However, the role and regulatory mechanism of CD177 protein of neutrophils in neuroinflammation remains elusive. Using single-cell RNA sequencing (scRNA-Seq), we characterized CD177high neutrophils as a novel anti-inflammatory subset in response to ischemic stroke.

2025-03-27 | GSE293098 | GEO

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on microglia in a co-culture system

Project description:To investigate the transcriptional effects of CD177+ neutrophils on microglia in spinal cord injuries (SCI), we adapted a co-culture system containing isolated neutrophils from Cd177 WT or KO mice post-SCI and isolated microglia. Each group had a biological repeat (n=3).

2024-09-10 | GSE276429 | GEO

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on macrophages in a co-culture system

Project description:To investigate the transcriptional effects of CD177+ neutrophils on macrophages in spinal cord injuries (SCI), we adapted a co-culture system containing isolated neutrophils from Cd177 WT or KO mice post-SCI and bone marrow-derived macrophages (BMDMs). Each group had a biological repeat (n=3).

2024-09-10 | GSE276427 | GEO

A Novel Role for A20-Regulated CNS Endothelial ICOSL in Immune Cell Adhesion and Autoimmune Neuroinflammation

Project description:A20 is a ubiquitin-modifying protein that negatively regulates canonical NF-κB signaling and mutations in A20/TNFAIP3 have been associated with a variety of autoimmune diseases, including multiple sclerosis (MS). We found that deletion of A20 in central nervous system (CNS) endothelial cells (BEC) enhances experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. These mice showed increased numbers of CNS-infiltrating immune cells during neuroinflammation and in the steady state. While the integrity of the barrier was not impaired, we observed a strong activation of the endothelium in A20ΔBEC mice, with dramatically increased levels of the adhesion molecules ICAM-1 and VCAM-1. We furthermore discovered ICOSL as novel adhesion molecule expressed by A20-deficient BECs. Silencing of ICOSL in BECs ameliorated the severity of an active EAE disease in wildtype mice and significantly delayed the onset of symptom development. Furthermore, blocking of ICOSL on primary CNS-derived endothelial cells impaired the adhesion of different T cell populations to the monolayer. Taken together, we here report a novel function of A20-regulated ICOSL expressed on CNS endothelial cells during inflammation. We propose that BEC-ICOSL contributes to the firm adhesion of T cells to the barrier, promoting T cell transmigration into the CNS and eventually driving autoimmune neuroinflammation.

2023-11-03 | GSE221318 | GEO

Cd177

Project description:Rattus norvegicus Cd177, CD177 molecule [Source:RGD Symbol;Acc:1562941], is expressed in 3 baseline experiment(s);

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CD177

Project description:Sus scrofa CD177, CD177 molecule [Source:VGNC Symbol;Acc:VGNC:86391], is expressed in 2 baseline experiment(s);

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CD177

Project description:Homo sapiens CD177, CD177 molecule [Source:HGNC Symbol;Acc:HGNC:30072], is differentially expressed in 77 experiment(s);

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Cd177

Project description:Mus musculus Cd177, CD177 antigen [Source:MGI Symbol;Acc:MGI:1916141], is differentially expressed in 80 experiment(s);

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CD177

Project description:Homo sapiens CD177, CD177 molecule [Source:HGNC Symbol;Acc:HGNC:30072], is expressed in 29 baseline experiment(s);

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Project description:Macaca mulatta CD177, CD177 molecule [Source:VGNC Symbol;Acc:VGNC:70912], is expressed in 3 baseline experiment(s);

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