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Leishmania infantum

ABSTRACT: The causal agent of visceral leishmaniasis in the Old World

PROVIDER: PRJNA12657 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR10478767_1.fastq.gz	Fastqsanger.gz
	SRR10478767_2.fastq.gz	Fastqsanger.gz
	SRR10478768_1.fastq.gz	Fastqsanger.gz
	SRR10478768_2.fastq.gz	Fastqsanger.gz

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Project description:The causal agent of visceral leishmaniasis in the Old World

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Blood transcription profiling of infections of humans with Leishmania infantum.

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Project description:Leishmania infantum (Kinetoplastida:Trypanosomatidae) is the etiological agent of zoonotic visceral leishmaniasis in the Mediterranean basin. The motile promastigote stage infects the hematophagous sand fly vector host and amastigotes survives and multiplies within phagocytes of the mammalian host. Promastigotes are routinely cultured in liquid undefined media and are considered to mimic the environment within the sand fly gut. We have put this to the test by high-throughput gene expression profiling by shotgun DNA microarrays generated in our laboratory. This has been possible thanks to RNA amplification.

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Project description:Leishmania infantum is the causative agent of visceral leishmaniasis in Latin America, a lethal disease if misdiagnosed or left untreated. The ubiquitin proteasome system (UPS) is the main regulator of intracellular proteolysis in eukaryotes and is required for parasite's to life cycle and infection. E3 ubiquitin ligases play important role in UPS and Cullin-1-RING ligases (CRL1) are the largest and most researched family of E3 in eukaryotes. CRL1 complex is made up of SKP1, Cullin1, RBX1, and F-box proteins. This complex is poorly studied in Leishmania. We investigated the interactome of CRL1 complex in L. infantum combining in vitro and in cellulo experiments to identify the interactome of Cullin1 and SKP1 through affinity purification followed by mass spectrometry analysis.

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