Danio rerio
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA127321 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Recent evidences have demonstrated phosphatidylinositol3-kinase (PI3-K)/Akt signaling pathway participates in cell growth, cell survival, and adipocyte differentiation in vitro. However, the in vivo evidence to support Akt function on adipogenesis is limited. To achieve this goal, we generated the stable zebrafish transgenics of Tg(krt4:myrAkt1)cy18 carrying human constitutive active form of Akt1 (myrAkt1) that driven by a skin-specific krt4 promoter. The Tg(krt4:myrAkt1)cy18 display severely skin hypertrophy at embryonic stages, and support Akt1 function as a key gene on cell size control. When transgenics reached sexual maturation, they display obese phenotype due to adipocyte hypertrophy and up-regulation of adipogenesis-related genes. Collectively, our findings provided a direct evidence to support Akt play provital roles on cell size control as well as adipogenesis in vivo. In addition, the obese zebrafish line of Tg(krt4:myrAkt1)cy18 provide a new platform to study obesity and its related chronic diseases mechanism in vivo.
2010-12-31 | GSE21756 | GEO
Project description:Ribosome Profiling over a Zebrafish Developmental Timecourse
| PRJNA200706 | ENA
Project description:Hypoxia induces myocardial regeneration in zebrafish
| PRJNA171838 | ENA
Project description:Gene expression analysis of diet induced obesity model zebrafish
| PRJNA121387 | ENA
Project description:Niclosamide Induces Epiboly Delay During Early Zebrafish Embryogenesis
| PRJNA454154 | ENA
Project description:RNA-Seq matched to ribosome profiling over a zebrafish developmental timecourse
| PRJNA288987 | ENA
Project description:Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish
| PRJNA391914 | ENA
Project description:Effect of obesity on liver immune response to inflammatory stimuli in a diet-obesity model of zebrafish (Danio rerio)
| PRJNA243389 | ENA
Project description:Creb overexpression induces leukemia in zebrafish by blocking myeloid differentiation process
| PRJNA290733 | ENA
Project description:Zebrafish (Danio rerio) model system have used widespread vertebrate investigations for genetic and cell biological analyses, and is suitable for small molecular screens such as chemical, toxicity and drug in order to use for human diseases and drug discovery . Recently, These powerful zebrafish model increasingly apply to human metabolic disease such as obesity and diabetes and toxicology. Despite a lot of advantages, proteomics research at zebrafish has received little interest in comparison with genetic and biological research using histology and in situ hybridization. Protein lysine acetylation is one of the most known post-translational modifications with dynamic and reversibly controlled by lysine acetyltransferase such as histone acetyltransferases and lysine deacetylase such as histone deacetylases and sirtuins family.Also, during the past year, global lysine acetylome studies using MS-based proteomics approach was in diverse species such as human, mouse, E. coli, Yeast and plants. Based on global acetylome data, our understanding of the roles of lysine acetylation in various cellular processes has increased. . The aim of this study was to identify Lysine acetylation in zebrafish embryos and determine the homology from Human at modified site level. Here we showed the global lysine acetylation study in Zebrafish embryos using MS-based zebrafish embryos.
2016-10-10 | PXD003455 | Pride