Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Expression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5

OTHER RELATED OMICS DATASETS IN: E-GEOD-21750

PROVIDER: PRJNA127339 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Cancer Patients

Project description:Oxaliplatin(OXA) chemotherapy protocols are used in treatment of cancers like colorectal (CRC) and pancreatic cancer. OXA causes peripheral neuropathy which is considered treatment limiting factor. In recent studies, it shows that omeprazole(OME) has antioxidant effect and can inhibit organic cation transporter 2 (OCT2) in kidney. So OME can protect against peripheral neuropathy induced by OXA through oxidative stress . Also OME activates extracellular-signal-regulated kinase(ERK) / mitogen activated protein kinase ( MAPK) pathway, so improves demyelinating symptoms.

| 4711 | ecrin-mdr-crc

Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells

Project description:Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which mediate tumour progression and poor prognosis. However, understanding of the crosstalk between cancer cells and fibroblasts in this disease is mostly lacking. Here, using co-cultures of patient-derived mesothelioma cell lines and lung fibroblasts, we demonstrate that fibroblast activation is a self-propagated process producing a fibrotic extracellular matrix (ECM) and triggering drug resistance in mesothelioma cells. Following characterisation of mesothelioma cells/fibroblasts signalling crosstalk, we identify several FDA-approved targeted therapies as far more potent than standard-of-care Cisplatin/Pemetrexed in ECM-embedded co-culture spheroid models. In particular, the SRC family kinase inhibitor, Saracatinib, extends overall survival well beyond standard-of-care in a mesothelioma genetically-engineered mouse model. In short, we lay the foundation for the rational design of novel therapeutic strategies targeting mesothelioma/fibroblast communication for the treatment of mesothelioma patients.

2024-01-26 | PXD040492 | Pride

Homo sapiens

Project description:Microarray data from CREB inhibited and control mesothelioma cells

| PRJNA223218 | ENA

Expression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5

Project description:Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO). Untransfected human mesothelial cells (LP9), MM cells (HMESO) or HMESO cells stably transfected with shControl, shERK1, shERK2 , or shERK5 plasmids were used. Microarrays were performed on samples from 3 independent experiments. Each sample was analyzed on a separate array (3 independent biological replicates).

2010-05-08 | E-GEOD-21750 | biostudies-arrayexpress

Homo sapiens

Project description:Genome wide extracellular signal-regulated kinase (ERK) pathway components interaction with human genome

| PRJNA273670 | ENA

Effect of culture system on gene expression during traditional 2D culture and 3D culture of mouse mesothelioma cells

Project description:To investigate the differences between mesothelioma- organoid culture and 2D traditional culture, we established 7 mesothelioma lines and 3 normal mesothelial cells from model mouse. We then performed gene expression profiling analysis using data obtained from RNA-seq of 20 different cells.

2022-12-22 | GSE210310 | GEO

Expression profile of maliganant mesothelioma cell lines

Project description:transcriptional profiling of makignant mesothelioma cell lines comparing control one immortalized mesothelial cell line, MeT-5A, and 2 primary normal mesothelial cultures collected from ascites of non-cancer patients, OV-M1 and GAS-M1 Two-condition experiment, mesothleioma cells vs. normal mesothelial cells

2011-12-18 | E-GEOD-34499 | biostudies-arrayexpress

A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancer

Project description:The purpose of this study is to determine the safety of an extracellular signal regulated kinase (ERK1/2) inhibitor LY3214996 administered alone or in combination with other agents in participants with advanced cancer.

| 2221663 | ecrin-mdr-crc

Gene expression profiles in MexTAg transgenic mouse and wild type mouse asbestos-induced mesothelioma

Project description:Malignant mesothelioma is an aggressive tumour arising from the mesothelial cells lining the pleura, peritoneum or pericardium. The principal carcinogen associated with malignant mesothelioma is asbestos . A transgenic mouse model, denoted MexTAg, which encodes the Simian Virus 40 (SV40) large T antigen (TAg) downstream of the mesothelin promoter was developed. Inactivation of the tumour suppressors p53 and RB following binding to TAg results. In this model mesothelioma develops in the mesothelial cell compartment after the mice have been exposed to asbestos. The MexTAg transgenic mouse model of mesothelioma model enables analysis of the molecular events associated with asbestos induced mesothelioma and is utilised here to investigate the molecular dynamics of tumours induced in these mice, using gene expression patterns as a read out.

2016-01-30 | E-MTAB-3988 | biostudies-arrayexpress

Transcription profiling of human mesothelioma cells MPP-89 REN compared to mesothelial cells HMC-TERT

Project description:gene expression profile of mesothelioma cells (MPP-89; REN) compared to mesothelial cells (HMC-TERT)

2008-10-09 | E-MEXP-1701 | biostudies-arrayexpress