Project description:Merm1/Wbscr22 is one of genes in chromosomal region deleted in Williams-Beuren syndrome, a multisystem developmental disorder. Wbscr22 contains a nuclear localization signal and an S-adenosyl-L-methionine-dependent methyltransferase fold, but its real function is completely unknown.　In this study, to examine the function, we compared the gene expression profiles between control and Merm1/Wbscr22 knock-downed tumor cells. Four established cell lines were selected for RNA extraction and hybridization on Affymetrix microarrays: (1) control LM8 cells, designated as LM8/control, (2) Merm1/Wbscr22 knock-downed LM8 cells, designated as LM8/shRNA, (3) control A375M cells, designated as A375M/control, and (4) Merm1/Wbscr22 knock-downed A375M cells, designated as A375M/shRNA.

| S-ECPF-GEOD-22065 | biostudies-other

Expression data from Hela cells upon knock-down of IRF2BP1 and IRF2BP2

Project description:Expression data from Hela cells upon knock-down of IRF2BP1 and IRF2BP2

| PRJNA679247 | ENA

Expression data from Merm1/Wbscr22 knock-down tumor cells

2010-09-01 | GSE22065 | GEO

Expression data from fibroblasts with knock-down of Brg1 and Brm

Project description:Expression data from fibroblasts with knock-down of Brg1 and Brm

| PRJNA595866 | ENA

Expression data from Merm1/Wbscr22 knock-down tumor cells

2010-09-01 | E-GEOD-22065 | biostudies-arrayexpress

Expression data from knock-down ES stable cell line

Project description:In order to identify the effects of the knock-down of the gene of interest on the mouse ES transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for the knock-down cell line. Transcriptome analysis of the knock-down transgenic mouse ES cell line. The knock-down cell line (shE13) was generated by stably expressing a specific short-hairpin RNA against E13 sequence thus knocking-down E13 expression in parental mouse ES cell line E14Tg2a.4 (E14, Hooper M et al., 1987). The specific mouse gene knocked down in the ES cell line is E130012A19Rik.

2012-12-13 | GSE31165 | GEO

CRISPR/Cas9 knock down line

Project description:CRISPR/Cas9 knock down line

| PRJNA521684 | ENA