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Mus musculus

ABSTRACT: Genome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes

PROVIDER: PRJNA128453 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR059269.fastq.gz	Fastqsanger.gz
	SRR059270.fastq.gz	Fastqsanger.gz
	SRR059271.fastq.gz	Fastqsanger.gz
	SRR059272.fastq.gz	Fastqsanger.gz
	SRR059273.fastq.gz	Fastqsanger.gz

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Genome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes

Project description:Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and physiology and showed that conditional ablation of Sin3 proteins in vivo in mouse results in sarcomere defects Examination of Sin3A and Sin3B binding during myogenesis

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