Lachancea kluyveri NRRL Y-12651
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ABSTRACT:
PROVIDER: PRJNA128809 | ENA |
REPOSITORIES: ENA
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Project description:Petite-negative budding yeast (known as Lachancea kluyveri or Saccharomyces kluyveri) sequenced for comparative genomics studies
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Project description:This SuperSeries is composed of the following subset Series: GSE22191: Absolute expression level of Debaryomyces hansenii genes GSE22192: Absolute expression level of Yarrowia lipolytica genes GSE22193: Absolute expression level of Saccharomyces paradoxus genes GSE22194: Absolute expression level of Candida glabrata genes GSE22197: Absolute expression level of Candida albicans genes GSE22198: Absolute expression level of Kluyveromyces lactis genes GSE22199: Absolute expression level of Kluyveromyces waltii genes GSE22200: Absolute expression level of Saccharomyces castellii genes GSE22201: Absolute expression level of Saccharomyces mikatae genes GSE22202: Absolute expression level of Saccharomyces kluyveryii genes GSE22204: Absolute expression level of Saccharomyces cerevisiae genes GSE22205: Absolute expression level of Saccharomyces bayanus genes GSE22211: Genome-wide nucleosome position data for 12 yeast species Refer to individual Series
2010-07-05 | E-GEOD-21960 | biostudies-arrayexpress
Project description:BackgroundThe characterization of DNA replication origins in yeast has shed much light on the mechanisms of initiation of DNA replication. However, very little is known about the evolution of origins or the evolution of mechanisms through which origins are recognized by the initiation machinery. This lack of understanding is largely due to the vast evolutionary distances between model organisms in which origins have been examined.ResultsIn this study we have isolated and characterized autonomously replicating sequences (ARSs) in Lachancea kluyveri - a pre-whole genome duplication (WGD) budding yeast. Through a combination of experimental work and rigorous computational analysis, we show that L. kluyveri ARSs require a sequence that is similar but much longer than the ARS Consensus Sequence well defined in Saccharomyces cerevisiae. Moreover, compared with S. cerevisiae and K. lactis, the replication licensing machinery in L. kluyveri seems more tolerant to variations in the ARS sequence composition. It is able to initiate replication from almost all S. cerevisiae ARSs tested and most Kluyveromyces lactis ARSs. In contrast, only about half of the L. kluyveri ARSs function in S. cerevisiae and less than 10% function in K. lactis.ConclusionsOur findings demonstrate a replication initiation system with novel features and underscore the functional diversity within the budding yeasts. Furthermore, we have developed new approaches for analyzing biologically functional DNA sequences with ill-defined motifs.
| S-EPMC3306766 | biostudies-literature