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Lodderomyces elongisporus NRRL YB-4239

ABSTRACT: WGS sequencing and assembly

PROVIDER: PRJNA12899 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	AAPO01.dat.gz	Other
	AAPO01.fasta.gz	Fasta.gz
	AAPO01.master.dat	Other
	AAPO01.dat.gz	Other

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Lodderomyces elongisporus NRRL YB-4239

Project description:Draft hybrid long-read assembly of Lodderomyces elongisporus NRRL YB-4239

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Expression analysis of Lodderomyces elongisporus NRRL YB-4239 grown in glucose or xylose

2011-10-20 | GSE24855 | GEO

Lodderomyces elongisporus NRRL YB-4239

Project description:Expression analysis of Lodderomyces elongisporus NRRL YB-4239 grown in glucose or xylose

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Expression analysis of Lodderomyces elongisporus NRRL YB-4239 grown in glucose or xylose

Project description:Investigation of whole genome gene expression level changes in Lodderomyces elongisporus NRRL YB-4239 grown aerobically in xylose, compared to the same strain grown aerobically in glucose. A six array study using total RNA recovered from three separate cultures of Lodderomyces elongisporus NRRL YB-4239 grown in glucose and three separate cultures of Lodderomyces elongisporus NRRL YB-4239 grown in xylose. Each array measures the expression level of 371,451 probes (average probe length 54.1 +/- 4.1 nt) tiled across the Lodderomyces elongisporus NRRL YB-4239 genome with a median spacing distance of 33 nt. During data processing, probes are filtered to include only those probes corresponding to annotated protein-coding genes.

2011-10-19 | E-GEOD-24855 | biostudies-arrayexpress

Lodderomyces elongisporus strain:NRRL YB-4239 (ATCC 11503)

Project description:Lodderomyces elongisporus strain:NRRL YB-4239 (ATCC 11503) Genome sequencing and assembly

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Lodderomyces elongisporus: a bloodstream pathogen of greater clinical significance.

Project description:The true clinical significance of Lodderomyces elongisporus remains underestimated as a result of problems associated with its identification by the VITEK 2 yeast identification system. Here we describe a case of L. elongisporus primary progressive fungaemia in a woman with no known risk factors for invasive fungal infections. The isolate was identified by PCR sequencing of the internally transcribed spacer region of ribosomal DNA. Despite treatment with caspofungin, the patient died within 3 days of onset of fungaemia. Our literature review highlights this organism's emerging role as a bloodstream pathogen. A need for application of molecular methods for its accurate identification is emphasized.

| S-EPMC6141678 | biostudies-literature

Lodderomyces elongisporus

Project description:A a case report for Lodderomyces elongisporus

| PRJNA954074 | ENA

Lodderomyces elongisporus

Project description:A yeast linked to nosocomial bloodstream infections

| PRJNA12822 | ENA

Isolation of Lodderomyces elongisporus from the Catheter Tip of a Fungemia Patient in the Middle East.

Project description:Lodderomyces elongisporus is phenotypically closely related to Candida parapsilosis and has recently been identified as an infrequent cause of bloodstream infections in patients from Asia and Mexico. We report here the isolation of Lodderomyces elongisporus from the catheter of a suspected case of fungemia. The identity of the isolate was confirmed by phenotypic characteristics and ribosomal DNA sequencing.

| S-EPMC3638566 | biostudies-literature

MTL genotypes, phenotypic switching, and susceptibility profiles of Candida parapsilosis species group compared to Lodderomyces elongisporus.

Project description:Reference isolates of Candida parapsilosis (n = 8), Candida metapsilosis (n = 6), Candida orthopsilosis (n = 7), and Lodderomyces elongisporus (n = 11) were analyzed to gain insight into their pathobiology and virulence mechanisms. Initial evaluation using BBL Chromagar Candida medium misidentified L. elongisporus isolates as C. albicans. Polymerase chain reaction analysis of isolate MTL idiomorphs revealed that all C. parapsilosis isolates were MTLa homozygous and no MTL α1, α2, a1, or a2 gene was detected in L. elongisporus isolates. For C. orthopsilosis, two isolates were MTLa homozygous and five were MTL-heterozygous. Similarly, one C. metapsilosis isolate was MTLα homozygous whereas five were MTL-heterozygous. Isolate phenotypic switching analysis revealed potential phenotypic switching in the MTLα homozygous C. metapsilosis isolate, resulting in concomitant elongated cell formation. Minimum inhibitory concentrations of fluconazole (FLC) and FK506, alone or in combination, were determined by checkerboard assay, with data analyzed using the fractional inhibitory concentration index model. Synergistic or additive effects of these compounds were commonly observed in C. parapsilosis and L. elongisporus isolates. No killer activity was observed in the studied isolates, as determined phenotypically. No significant difference in virulence was seen for the four species in a Galleria mellonella model (P > 0.05). In conclusion, our results demonstrated phenotypic switching of C. metapsilosis CBS 2315 and that FLC and FK506 represent a promising drug combination against C. parapsilosis and L. elongisporus. The findings of the present study contribute to our understanding of the biology, diagnosis, and new possible treatments of the C. parapsilosis species group and L. elongisporus.

| S-EPMC5542550 | biostudies-literature

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