Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA129081 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Conditional Dmrt1 knockout gene expression (phase 8)
| PRJNA129087 | ENA
Project description:Conditional Dmrt1 knockout gene expression (phase 7)
| PRJNA129085 | ENA
Project description:This SuperSeries is composed of the following subset Series: GSE22500: Conditional Dmrt1 knockout gene expression (phase 6) GSE22507: Conditional Dmrt1 knockout gene expression (phase 7) GSE22508: Conditional Dmrt1 knockout gene expression (phase 8) Refer to individual Series
2010-06-30 | E-GEOD-22510 | biostudies-arrayexpress
Project description:Dmrt1 (doublesex and mab-3 related transcription factor 1) conditional knockout expression analysis of E15.5 testes.
| PRJNA178416 | ENA
Project description:Dmrt1 (doublesex and mab-3 related transcription factor 1) conditional knockout expression analysis of P28 testes
| PRJNA137157 | ENA
Project description:Dmrt1 (doublesex and mab-3 related transcription factor 1) conditional knockout expression analysis of E15.5 ovaries.
| PRJNA178417 | ENA
Project description:To characterize the genetic basis of hybrid male sterility in detail, we used a systems genetics approach, integrating mapping of gene expression traits with sterility phenotypes and QTL. We measured genome-wide testis expression in 305 male F2s from a cross between wild-derived inbred strains of M. musculus musculus and M. m. domesticus. We identified several thousand cis- and trans-acting QTL contributing to expression variation (eQTL). Many trans eQTL cluster into eleven ‘hotspots,’ seven of which co-localize with QTL for sterility phenotypes identified in the cross. The number and clustering of trans eQTL - but not cis eQTL - were substantially lower when mapping was restricted to a ‘fertile’ subset of mice, providing evidence that trans eQTL hotspots are related to sterility. Functional annotation of transcripts with eQTL provides insights into the biological processes disrupted by sterility loci and guides prioritization of candidate genes. Using a conditional mapping approach, we identified eQTL dependent on interactions between loci, revealing a complex system of epistasis. Our results illuminate established patterns, including the role of the X chromosome in hybrid sterility.
2014-05-01 | GSE54089 | GEO
Project description:The replication timing program, or the order in which DNA is duplicated during S-phase, is associated with various features of chromosome structure and function, including gene expression, histone modifications, and 3-D compartmentalization of chromatin.
2013-04-16 | GSE45716 | GEO
Project description:Total Gene expression analysis of H3f3b conditional knockout MEFs
| PRJNA156025 | ENA