Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Drosophila melanogaster

ABSTRACT: Drosophila melanogaster gene expression changes after spaceflight.

OTHER RELATED OMICS DATASETS IN: E-GEOD-23880

PROVIDER: PRJNA130611 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Drosophila melanogaster gene expression changes after spaceflight.

Project description:Gene expression levels were determined in 3rd instar and adult Drosophila melanogaster reared during spaceflight, to elucidate the genetic and molecular mechanisms underpinning the effects of microgravity on the immune system. The goal was to validate the Drosophila model for understanding alterations of innate immune responses in humans due to spaceflight. Five containers of flies, with ten female and five male fruit flies in each container, were housed and bred on the space shuttle (average orbit altitude of 330.35 km) for 12 days and 18.5 hours, with a new generation reared in microgravity. RNA was extracted on the day of shuttle landing from whole body animals (3rd instar larvae and adults), hybridized to Drosophila 2.0 Affymetrix genome arrays, and the expression level of all genes was normalized against the gene expression level from the corresponding developmental stage animals raised on ground. Spaceflight altered the expression of larval genes involved in the maturation of plasmatocytes (macrophages) and their phagocytic response, as well as the level of constitutive expression of pattern recognition receptors and opsonins that specifically recognize bacteria, and of lysozymes, antimicrobial peptide pathway and immune stress genes, hallmarks of humoral immunity.

2011-09-01 | GSE23880 | GEO

Drosophila melanogaster

Project description:Microbiota-Induced Gene Expression Changes in the Drosophila melanogaster Head

| PRJNA514099 | ENA

Drosophila melanogaster

Project description:Parasitoid wasp induced changes in gene expression in Drosophila melanogaster

| PRJNA685781 | ENA

Drosophila melanogaster

Project description:Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster.

| PRJNA206856 | ENA

Drosophila melanogaster proteome dynamics during embryogenesis - 1

Project description:In this study we use a combination of proteomics Label-Free quantification methods to monitor protein expression changes over a time course of more than 20 hours of embryo development in Drosophila melanogaster.

2016-04-11 | PXD003178 | Pride

Drosophila melanogaster