Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Legionella pneumophila str. Lens

ABSTRACT: Organism responsible for major oubreak of legionellosis in France

PROVIDER: PRJNA13126 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	GCA_000048665.1_sequence_report.txt	Txt

Items per page:

1 - 1 of 1

Similar Datasets

Legionella pneumophila str. Paris

Project description:Endemic organism in France responsible for legionellosis

| PRJNA13127 | ENA

Legionella pneumophila str. Corby

Project description:Causative agent of legionellosis

| PRJNA17491 | ENA

Legionella pneumophila subsp. pneumophila

Project description:Genome sequencing of Legionella pneumophila subsp. pneumophila isolates from 2005 and 2008 Legionellosis outbreak in Fredrikstad, Norway

| PRJNA337897 | ENA

Legionella pneumophila subsp. pneumophila strain:Lens

Project description:Type I-F CRISPR-Cas distribution and array dynamics in Legionella pneumophila

| PRJNA433194 | ENA

Transcriptome of Legionella pneumophila rpoS mutant in water

Project description:Legionella pneumophila is a water-borne pathogen, and thus survival in the aquatic environment is central to its transmission to humans. Hence, identifying genes required for its survival in water could help prevent Legionnaires’ disease outbreaks. In the present study, we investigate for the first time the role of the sigma factor RpoS in promoting the survival in water, where L. pneumophila experiences total nutrient deprivation. The rpoS mutant showed a significant survival defect compared to the wild-type strain in defined water medium (DFM). Then, we analyzed the transcriptome of the rpoS mutant during exposure to water using whole genome microarray analysis. We found that RpoS negatively affects the expression of several genes, including genes required for replication, cell division, translation and transcription, suggesting that the mutant fails to shutdown major metabolic programs.

2014-12-04 | GSE56258 | GEO

Transcriptomic change of Legionella pneumophila in water.

Project description:Legionella pneumophila (Lp) is an opportunistic pathogen and its survival in water is critical for human infection. Therefore, identifying the genes of Lp that are required for survival in water may help devise strategies to prevent Legionella outbreaks. In this study, we exposed Lp in rich medium and in an artificial freshwater medium (Fraquil) for 2, 6 and 24 hours to uncover the global transcriptomic changes of Lp in water. The repression of major metabolic pathways, such as division, transcription and translation, suggests that Lp enters a dormant state in water. The induction of the flagellar associated genes (flg, fli and mot), enhance entry genes (enh) and some Icm/Dot effectors suggests that Lp may be waiting to establish intracellular replication in suitable host. Moreover, many genes involved in resistance to antibiotic and oxidative stress were induced, suggesting that Lp may be more tolerant to environmental stresses in water. Indeed, Lp exposed to water is more resistant to erythromycin, gentamycin and kanamycin than those cultured in rich medium. Apart from this, the gene bdhA involved in the degradation of the intracellular energy storage compound poly-hydroxybutyrate is highly expressed in water. Further characterization shows that bdhA is positively regulated by RpoS during short-term exposure to water. The deletion mutant of bdhA had a survival defect in water at 37°C, demonstrating that this gene is important for maintaining the long-term survivorship of Lp in water. Other identified genes highly induced upon exposure to water could also be necessary for Lp to survive in water.

2014-11-26 | GSE63622 | GEO

Legionella pneumophila str. 121004

Project description:Legionella pneumophila str. 121004 Genome sequencing and assembly

| PRJNA214447 | ENA

Legionella pneumophila str. Corby

Project description:Legionella pneumophila str. Corby Genome sequencing and assembly

| PRJNA904548 | ENA

Legionella pneumophila str. Paris

Project description:The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system

| PRJNA368718 | ENA

Legionella pneumophila subsp. pneumophila str. lorraine

Project description:Legionella pneumophila subsp. pneumophila str. Lorraine genome sequencing project