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Actinobacillus succinogenes 130Z strain:ATCC55618

ABSTRACT: A succinate-producing bacteria used by the pharmaceutical industry

PROVIDER: PRJNA13370 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR097466_1.fastq.gz	Fastqsanger.gz
	SRR097466_2.fastq.gz	Fastqsanger.gz
	SRR190859_1.fastq.gz	Fastqsanger.gz
	SRR190859_2.fastq.gz	Fastqsanger.gz
	SRR190862_1.fastq.gz	Fastqsanger.gz

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Actinobacillus succinogenes

Project description:Succinate-producing bacterium

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Transcriptome of aerobically/anaerobically grown Actinobacillus succinogenes strain 130Z on fumarate/glucose

Project description:Transcriptome of aerobically/anaerobically grown Actinobacillus succinogenes strain 130Z on fumarate/glucose

2016-12-22 | GSE92722 | GEO

Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z.

Project description:BackgroundActinobacillus succinogenes is a promising bacterial catalyst for the bioproduction of succinic acid from low-cost raw materials. In this work, a genome-scale metabolic model was reconstructed and used to assess the metabolic capabilities of this microorganism under producing conditions.ResultsThe model, iBP722, was reconstructed based on the functional reannotation of the complete genome sequence of A. succinogenes 130Z and manual inspection of metabolic pathways, covering 1072 enzymatic reactions associated with 722 metabolic genes that involve 713 metabolites. The highly curated model was effective in capturing the growth of A. succinogenes on various carbon sources, as well as the SA production under various growth conditions with fair agreement between experimental and predicted data. Calculated flux distributions under different conditions show that a number of metabolic pathways are affected by the activity of some metabolic enzymes at key nodes in metabolism, including the transport mechanism of carbon sources and the ability to fix carbon dioxide.ConclusionsThe established genome-scale metabolic model can be used for model-driven strain design and medium alteration to improve succinic acid yields.

| S-EPMC5975692 | biostudies-literature

Actinobacillus succinogenes 130Z

Project description:Actinobacillus succinogenes 130Z, A1 genome sequencing

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Actinobacillus succinogenes 130Z

Project description:Actinobacillus succinogenes 130Z, C1 genome sequencing

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Actinobacillus succinogenes 130Z

Project description:Actinobacillus succinogenes 130Z, G1 genome sequencing

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Actinobacillus succinogenes 130Z

Project description:Actinobacillus succinogenes 130Z, H1 genome sequencing