Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

ABSTRACT: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

PROVIDER: PRJNA147047 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR350899.fastq.gz	Fastqsanger.gz
	SRR350900.fastq.gz	Fastqsanger.gz
	SRR350901.fastq.gz	Fastqsanger.gz
	SRR350902.fastq.gz	Fastqsanger.gz
	SRR350903.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

Project description:We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslational modification. The unique structure and genomic localization of histone Kcr suggest that it is mechanistically and functionally different from histone lysine acetylation (Kac). Specifically, in both human somatic and mouse male germ cell genomes, histone Kcr marks either active promoters or potential enhancers. In male germinal cells immediately following meiosis, Kcr is enriched on sex chromosomes and specifically marks testis-specific genes, including a significant proportion of X-linked genes that escape sex chromosome inactivation in haploid cells. These results therefore dramatically extend the repertoire of histone PTM sites and designate Kcr as a specific mark of active sex chromosome-linked genes in postmeiotic male germ cells. 2 histone marks (pan-lysine acetylation and pan-lysine crotonylation) were studied in 1 human cell type and 2 mouse cell types using ChIP-Seq. Input was sequenced for each cell type as a control. Pan-anti_Kac and pan-anti_Kcr antibodies were custom developed with PTM BioLab, Co., Ltd (Chicago, IL).

2011-10-06 | E-GEOD-32663 | biostudies-arrayexpress

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

2011-10-06 | GSE32663 | GEO

Histone Lysine Crotonylation Regulates Long-Term Memory Storage

Project description:Utilizing a single nuclei multiomics approach, this study elucidates how enhancing histone lysine crotonylation regulates cell type specific gene expression and chromatin accessibility during memory consolidation.

2024-11-13 | GSE281007 | GEO

Histone Lysine Crotonylation Regulates Long-Term Memory Storage

Project description:Histone Lysine Crotonylation Regulates Long-Term Memory Storage

| PRJNA1181824 | ENA

Lysine Catabolism Reprograms Tumour Immunity through Histone Crotonylation.

Project description:Lysine Catabolism Reprograms Tumour Immunity through Histone Crotonylation.

| PRJNA860225 | ENA

Histone crotonylation

Project description:Histone crotonylation

| PRJNA535529 | ENA

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

| S-EPMC3176443 | biostudies-literature

Genome-wide profiling of histone lysine crotonylation reveals positive regulation of transcription in rice

Project description:Histone lysine crotonylation (Kcr) is a newly discovered post-translational modification (PTM) existing in mammalian. To assess relevance in histone Kcr and genome, we performed on genomic localization analysis of histone Kcr by ChIP-seq analysis.

2018-06-01 | GSE108542 | GEO

P300 Regulates Histone Crotonylation and Preimplantation Embryo Development (RNA-Seq)

Project description:Histone lysine crotonylation is a non-acetyl histone lysine modification that is evolutionarily conserved. It plays an important role in regulating various biological processes, including gene transcriptional regulation, spermatogenesis, and cell cycle. However, the dynamic changes and functions of histone crotonylation in preimplantation embryonic development in mammals remain unclear. In this study, we have shown that the transcription coactivator P300 functions as a writer of histone crotonylation during embryonic development. Depletion of P300 resulted in significant developmental defects and dysregulation of the transcriptome of embryos. Importantly, we demonstrated that P300 catalyzes the crotonylation of histone, directly stimulating transcription and regulating gene expression, thereby ensuring successful embryo development to the blastocyst stage. Furthermore, it is showed that the histone H3 lysine 18 crotonylation (H3K18cr) modification is predominantly located in active promoter regions. It serves as an epigenetic hallmark of key transcriptional regulators and promotes the transcription activation of genes. Together, our results propose a model wherein P300-mediated histone crotonylation plays a crucial role in regulating the fate of embryonic development.

2024-06-18 | GSE241194 | GEO

P300 Regulates Histone Crotonylation and Preimplantation Embryo Development (ChIP-Seq)

2024-06-18 | GSE241193 | GEO