Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA152201 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:The homeobox gene HOXA10 plays a key role in endometrial differentiation during embryogenesis and is abundantly expressed in the adult endometrium and decidual cells. In the adult endometrium the expression of HOXA10 is regulated by estrogen and progesterone and the levels are highest in the decidualized cells. We have shown that HOXA10 is required in the endometrial cells to maintain the decidual cell phenotype. In this study we aimed to determine the molecular mechanisms by which HOXA10 maintains the decidual phenotype and the other roles it might have in decidual physiology. In vitro decidualized human endometrial stromal cells were knocked down for HOXA10 using siRNA and gene expression profiles of the scrambled and HOXA10 siRNA transfected cells were compared at 24, 48 and 72 h post transfection. Several genes having multiple functions were found to be differentially expressed. We postulate that HOXA10 is required by the decidual cells to support immune cell differentiation, trophoblast invasion and cellular remodeling. In vitro decidualized priamry cultures of human endometrial strmal cells transfected with a siRNA againts HOXA10 or a scrambled siRNA. Cells harvested at 24, 48 and 72 h post transfection. Dual channel hybridization with dye swap design in biological replicates
2012-02-14 | E-GEOD-35801 | biostudies-arrayexpress
Project description:The homeobox gene HOXA10 plays a key role in endometrial differentiation during embryogenesis and is abundantly expressed in the adult endometrium and decidual cells. In the adult endometrium the expression of HOXA10 is regulated by estrogen and progesterone and the levels are highest in the decidualized cells. We have shown that HOXA10 is required in the endometrial cells to maintain the decidual cell phenotype. In this study we aimed to determine the molecular mechanisms by which HOXA10 maintains the decidual phenotype and the other roles it might have in decidual physiology. In vitro decidualized human endometrial stromal cells were knocked down for HOXA10 using siRNA and gene expression profiles of the scrambled and HOXA10 siRNA transfected cells were compared at 24, 48 and 72 h post transfection. Several genes having multiple functions were found to be differentially expressed. We postulate that HOXA10 is required by the decidual cells to support immune cell differentiation, trophoblast invasion and cellular remodeling.
2012-02-14 | GSE35801 | GEO
Project description:miRNA expression profiles in decidualized and non-decidualized normal endometrial stromal cells (NESCs).
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Project description:mRNA expression profiles in decidualized and non-decidualized normal endometrial stromal cells (NESCs).
| PRJNA304178 | ENA
Project description:WNK1-dependent transcriptome in decidualized human endometrial stromal cells
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Project description:Progesterone Receptor- and FOXO1-dependent transcriptomes decidualized human endometrial stromal cells
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Project description:To clarify mineralcorticoid receptor and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Genome-wide microarray analysis was performed on primary cultures established from 4 different patients. Stromal cell cultures were subjected to either GR or MR siRNA knockdown or control non-targeting siRNA then decidualized for four days before harvesting and RNA extraction for microarray analysis.
2012-11-28 | E-GEOD-42538 | biostudies-arrayexpress
Project description:Progesterone receptor transcriptome and cistrome in decidualized human endometrial stromal cells [ChIP]
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Project description:mRNA expression profiles in decidualized and non-decidualized endometriotic cyst stromal cells (ECSCs).
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Project description:miRNA expression profiles in decidualized and non-decidualized endometriotic cyst stromal cells (ECSCs).
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