Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: A high throughput in vivo protein-DNA mapping approach reveals principles of dynamic gene regulation in mammals (RNA-Seq)

OTHER RELATED OMICS DATASETS IN: GSE36104

PROVIDER: PRJNA155803 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1821189_1.fastq.gz	Fastqsanger.gz
	SRR1821189_2.fastq.gz	Fastqsanger.gz
	SRR414887_1.fastq.gz	Fastqsanger.gz
	SRR414887_2.fastq.gz	Fastqsanger.gz
	SRR414888_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Project description:A high throughput in vivo protein-DNA mapping approach reveals principles of dynamic gene regulation in mammals

| PRJNA152977 | ENA

Mus musculus

Project description:A high throughput in vivo protein-DNA mapping approach reveals principles of dynamic gene regulation in mammals (ChIP-Seq)

| PRJNA155801 | ENA

Dynamic landscape of RNA structures in vivo reveals principles of post-transcriptional regulation

Project description:Dynamic landscape of RNA structures in vivo reveals principles of post-transcriptional regulation

| PRJNA270325 | ENA

Mus musculus

Project description:Dynamic landscape of RNA structures in vivo reveals principles of post-transcriptional regulation [iCLIP]

| PRJNA270334 | ENA

Mus musculus

Project description:Dynamic landscape of RNA structures in vivo reveals principles of post-transcriptional regulation [icSHAPE]

| PRJNA257310 | ENA

An atlas of protein-protein interactions across mouse tissues

Project description:Cellular processes arise from the dynamic organization of proteins in networks of physical interactions. Mapping the complete network of biologically relevant protein-protein interactions, the interactome, has therefore been a central objective of high-throughput biology. However, the dynamics of protein interactions across physiological contexts are poorly understood. Here, we apply a quantitative proteomic approach combining protein correlation profiling with stable isotope labelling of mammals (PCP–SILAM) to map the interactomes of seven mouse tissues, revealing over 3527,000 unique interactions with an accuracy comparable to the highest-quality human screens. We identify systematic suppression of cross-talk between the evolutionarily ancient housekeeping interactome and younger, tissue-specific modules. Rewiring of protein interactions across tissues is widespread, and rewired proteins are tightly regulated by multiple cellular mechanisms and implicated in disease. Our study opens up new avenues to uncover regulatory mechanisms that shape in vivo interactome responses to physiological and pathophysiological stimuli in mammalian systems.

2022-02-22 | PXD012009 | Pride

Targeted high throughput mutagenesis of the human spliceosome reveals its in vivo operating principles

Project description:Targeted high throughput mutagenesis of the human spliceosome reveals its in vivo operating principles

| PRJNA903130 | ENA

Global Analysis of the RNA-Protein Interaction and RNA Secondary Structure Landscapes Identifies Dynamic Changes During Mammalian Erythropoiesis (mRNA)

Project description:Two features of eukaryotic RNA molecules that regulate their post-transcriptional fates are RNA secondary structure and RNA-binding protein (RBP) interaction sites. However, a comprehensive global overview of the dynamic nature of these sequence features during erythropoiesis has never been obtained. Here, we use our ribonuclease-mediated structure and RBP-binding site mapping approach to reveal the global landscape of RNA secondary structure and RBP-RNA interaction sites and the dynamics of these features during this important developmental process. We identify dynamic patterns of RNA secondary structure and RBP binding that are consistently anti-correlated throughout mRNAs during erythropoiesis. Additionally, we determine a set of protein-bound sequence motifs and their dynamic structural and RBP binding contexts. Finally, using these dynamically bound sequences, we identify a number of RBPs that have known and putative key functions in post-transcriptional regulation during mammalian erythropoiesis. In total, this global analysis reveals new post-transcriptional regulators of mammalian blood cell development.

2021-07-23 | GSE148421 | GEO

DamC reveals principles of chromatin folding in vivo without crosslinking and ligation [capture-mapping]

Project description:DamC reveals principles of chromatin folding in vivo without crosslinking and ligation [capture-mapping]

| PRJNA526051 | ENA

Targeted high throughput mutagenesis of the human spliceosome reveals its in vivo operating principles [editing]

Project description:Targeted high throughput mutagenesis of the human spliceosome reveals its in vivo operating principles [editing]

| PRJNA903135 | ENA