Project description:This SuperSeries is composed of the following subset Series: GSE33145: Expression data from DKAT and other breast cancer cell lines under baseline growth conditions GSE33146: Expression data from DKAT breast cancer cell line pre- and post-EMT Refer to individual Series
Project description:This is a dynamic pathway model capturing ERBB receptor signaling as well as downstream MAPK and PI3K signaling pathways. The effect of different growth factors and drugs on the formation of active receptor dimers is explicitly included. The model was established and calibrated on time-resolved data of the luminal breast cancer cell lines MCF7 and T47D across an array of four ligands and five drugs. For the description of the full modeling project including condition-specific parameters, observables, measurement data and experimental conditions the model is provided in PEtab format in addition to the classical SBML version.
