Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Nonomuraea coxensis

ABSTRACT: Nonomuraea coxensis overview

PROVIDER: PRJNA169279 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	ARBV01.dat.gz	Other
	ARBV01.fasta.gz	Fasta.gz
	ARBV01.master.dat	Other
	SRR13495179_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 7

Similar Datasets

Nonomuraea coxensis DSM 45129

Project description:Nonomuraea coxensis DSM 45129 Genome sequencing and assembly

| PRJNA693185 | ENA

Nonomuraea coxensis DSM 45129

Project description:Nonomuraea coxensis DSM 45129 Genome sequencing and assembly

| PRJNA165411 | ENA

Nonomuraea

Project description:Nonomuraea sp. overview

| PRJNA299243 | ENA

Nonomuraea pusilla

Project description:Nonomuraea pusilla overview

| PRJNA641956 | ENA

Nonomuraea gerenzanensis

Project description:Nonomuraea gerenzanensis overview

| PRJNA975660 | ENA

Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by <i>Nonomuraea coxensis</i> DSM 45129.

Project description:Glycopeptide antibiotics (GPAs) are last defense line drugs against multidrug-resistant Gram-positive pathogens. Natural GPAs teicoplanin and vancomycin, as well as semisynthetic oritavancin, telavancin, and dalbavancin, are currently approved for clinical use. Although these antibiotics remain efficient, emergence of novel GPA-resistant pathogens is a question of time. Therefore, it is important to investigate the natural variety of GPAs coming from so-called "rare" actinobacteria. Herein we describe a novel GPA producer-Nonomuraea coxensis DSM 45129. Its de novo sequenced and completely assembled genome harbors a biosynthetic gene cluster (BGC) similar to the dbv BGC of A40926, the natural precursor to dalbavancin. The strain produces a novel GPA, which we propose is an A40926 analogue lacking the carboxyl group on the N-acylglucosamine moiety. This structural difference correlates with the absence of dbv29-coding for an enzyme responsible for the oxidation of the N-acylglucosamine moiety. Introduction of dbv29 into N. coxensis led to A40926 production in this strain. Finally, we successfully applied dbv3 and dbv4 heterologous transcriptional regulators to trigger and improve A50926 production in N. coxensis, making them prospective tools for screening other Nonomuraea spp. for GPA production. Our work highlights genus Nonomuraea as a still untapped source of novel GPAs.

| S-EPMC8291499 | biostudies-literature

Micromonospora coxensis strain:dsm 45161

Project description:Micromonospora coxensis DSM 45161 genome sequencing

| PRJNA303511 | ENA

Catellatospora coxensis strain:NBRC 107359

Project description:Catellatospora coxensis NBRC 107359 genome sequencing project

| PRJDB9954 | ENA

Nonomuraea gerenzanensis

Project description:Nonomuraea gerenzanensis Genome sequencing

| PRJNA765517 | ENA

Nonomuraea sp.

Project description:Nonomuraea sp. Raw sequence reads