Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Selective lymphoma cell killing by a PRC2 small molecule inhibitor

ABSTRACT: Selective lymphoma cell killing by a PRC2 small molecule inhibitor

PROVIDER: PRJNA174125 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR548186.fastq.gz	Fastqsanger.gz
	SRR548187.fastq.gz	Fastqsanger.gz
	SRR548188.fastq.gz	Fastqsanger.gz
	SRR548189.fastq.gz	Fastqsanger.gz
	SRR548190.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 80

Similar Datasets

Selective lymphoma cell killing by a PRC2 small molecule inhibitor

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-01 | GSE40476 | GEO

Homo sapiens

Project description:Selective lymphoma cell killing by a PRC2 small molecule inhibitor (RNA-Seq)

| PRJNA174129 | ENA

Homo sapiens

Project description:Selective lymphoma cell killing by a PRC2 small molecule inhibitor (Exon array)

| PRJNA174128 | ENA

Selective lymphoma cell killing by a PRC2 small molecule inhibitor (RNA-Seq)

Project description:Genome-wide gene expression changes in response to iEZH treatment in HT and SUDHL6 cells using RNA sequencing (RNA-seq).

2020-12-01 | GSE40475 | GEO

Selective lymphoma cell killing by a PRC2 small molecule inhibitor (Exon array)

Project description:Microarray-based expression analysis in HT and SUDHL6 cell lines.

2020-12-01 | GSE40474 | GEO

EED226, an allosteric PRC2 inhibitor, modulates gene transcription in EZH2 mutant lymphoma cell Karpas422 through PRC2 inhibition

Project description:Polycomb repressive complex (PRC) 2, containing minimally EZH2, EED and Suz12, is the H3 lysine 27 methyltransferase playing pivotal roles in transcriptional regulation. EZH2 is the catalytic subunit, and H3K27me3 activates PRC2 through binding EED to propagate the repressive mark. Cofactor SAM-competitive (SAM-C) PRC2 inhibitors (PRC2is) have been discovered to treat lymphoma and rhabdoid tumors. Here we report the discovery of EED226, a potent and selective PRC2i directly binding to the H3K27me3 pocket of EED. Upon binding, EED226 induces conformational change in EED protein. Interestingly, it inhibits both the basal and the H3K27me3-stimulated PRC2 activities. Furthermore, EED226 selectively pulled down the endogenous PRC2 complex from human cell lysates, specifically modulates H3K27 methylation and target genes similarly as SAM-C PRC2 inhibitors, and effectively regresses human lymphoma xenograft tumor in mouse. More importantly, EED226 potently inhibits the SAM-C inhibitor-resistant PRC2 and synergizes with SAM-C PRC2i in cell proliferation blocking. Together, EED226 is an inhibitor of PRC2 with a novel mechanism and represent a potential complementary strategy for PRC2-targeted cancer therapy.

2017-01-30 | GSE81267 | GEO

Homo sapiens

Project description:Selective lymphoma cell killing by a PRC2 small molecule inhibitor (ChIP-Seq set 1)

| PRJNA174126 | ENA

Homo sapiens

Project description:Selective lymphoma cell killing by a PRC2 small molecule inhibitor (ChIP-Seq set 2)

| PRJNA174127 | ENA

Selective lymphoma cell killing by a PRC2 small molecule inhibitor (ChIP-Seq set 2)

Project description:Genome-wide distribution of EZH2, H3K27me3 and H3K36me1 determined by ChIP-seq in SUDHL6 cells in the absence or presence of iEZH

2020-12-01 | GSE40473 | GEO

Selective lymphoma cell killing by a PRC2 small molecule inhibitor (ChIP-Seq set 1)

Project description:Genomewide H3K27me3 and H3K4me3 patterns and EZH2 binding profiles in HT and SUDHL6 cell lines by chromatin immunoprecipitation and deep sequencing (ChIP-seq).

2020-12-01 | GSE40472 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data