PAGE: CALiCo: Hispanic Community Health Study / Study of Latinos (HCHS/SOL)
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA176953 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Hispanic Community Health Study / Study of Latinos (HCHS/SOL)
| PRJNA263099 | ENA
Project description:NHLBI TOPMed: Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
| PRJNA392482 | ENA
Project description:<p>The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) is a multi-center epidemiologic study in Hispanic/Latino populations to determine the role of acculturation in the prevalence and development of disease, and to identify risk factors playing a protective or harmful role in Hispanics/Latinos. The study is sponsored by the National Heart, Lung, and Blood Institute (NHLBI) and six other institutes, centers, and offices of the National Institutes of Health (NIH).</p> <p>The goals of the HCHS/SOL include studying the prevalence and development of disease in Hispanics/Latinos, including the role of acculturation, and identifying disease risk factors that play protective or harmful roles in Hispanics/Latinos. A total of 16,415 persons of Cuban, Dominican, Mexican, Puerto Rican, Central American, and South American backgrounds were recruited through four Field Centers affiliated with San Diego State University, Northwestern University in Chicago, Albert Einstein College of Medicine in the Bronx area of New York, and the University of Miami. Seven additional academic centers serve as scientific and logistical support centers.</p> <p>Study participants aged 18-74 years took part in an extensive clinic exam and assessments to ascertain socio-demographic, cultural, environmental and biomedical characteristics. Annual follow-up interviews are conducted to determine a range of health outcomes.</p> <p><b>The HCHS SOL Cohort is utilized in the following dbGaP sub-studies.</b> To view genotypes, other molecular data, and derived variables collected in these sub-studies, please click on the following sub-studies below or in the "Sub-studies" box located on the right hand side of this top-level study page <a href="study.cgi?study_id=phs000810">phs000810</a> HCHS SOL Cohort. <ul> <li><a href="study.cgi?study_id=phs000555">phs000555</a> PAGE CALiCo SOL</li> <li><a href="study.cgi?study_id=phs000880">phs000880</a> HCHS/SOL Omics in Latinos (Ola)</li> </ul> </p>
| phs000810 | dbGaP
Project description:PAGE: CALiCo: Hispanic Community Health Study / Study of Latinos (HCHS/SOL)
| PRJNA176954 | ENA
Project description:Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
| PRJNA835958 | ENA
Project description:Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
| PRJNA835957 | ENA
Project description:<p>This study contains whole genome sequence data. A case-control sample of individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a multicenter prospective cohort study of 16,415 persons of Cuban, Dominican, Mexican, Puerto Rican, Central American, and South American background (<a href="study.cgi?study_id=phs000810">phs000810</a>), was selected for whole genome sequencing, including participants with a history of physician-diagnosed asthma and asthma-free participants.</p>
| phs001395 | dbGaP
Project description:BACKGROUND:Seven national 2020 Strategic Impact Goals for cardiovascular health (Life's Simple 7 [LS7]) estimates for major ethnic/racial groups are available, but not for diverse Hispanics/Latinos. Herein, we describe and examine LS7 profiles of diverse Hispanic/Latino groups. METHODS:HCHS/SOL (analytic n = 15,825; ages 18-74 years) data were used to estimate LS7 metrics. LS7 metrics were operationalized as Ideal, Intermediate, or Poor and indexed as an additive score. We calculated Hispanic/Latino group and sex-specific prevalence estimates for LS7 metrics and used survey-based regression models to examine (1) associations between LS7 scores and pertinent sociocultural characteristics and (2) relationships between LS7 scores and coronary heart disease, and stroke and transient ischemic attacks prevalence. RESULTS:Few HCHS/SOL participants met all 7 Ideal LS7 criteria (<1%), and a similarly small proportion did not meet any Ideal LS7 criteria (1.1%). We found significant variability in LS7 distributions between men and women and across HCHS/SOL Hispanic/Latino heritages. We also found a substantial sex-adjusted age gradient in LS7 cardiovascular health (ie, ?4 Ideal LS7s). Finally, higher Ideal LS7 scores were associated with decreased odds of both coronary heart disease and self-reported stroke/transient ischemic attack; these associations persisted after model covariate adjustments. CONCLUSIONS:Hispanic/Latino LS7s compared favorably with existing national estimates; however, we found areas for improvement. Several Hispanic/Latino LS7 strengths and weaknesses varied by sex and heritage, providing important information to guide targeted health promotion efforts toward achieving 2020 goals.
| S-EPMC5479416 | biostudies-literature
Project description:<p>PAGE II (2013-2017) seeks to expand understanding gained during PAGE I and similar studies of how ancestry-specific differences in allele frequencies and LD may explain differences in risks of common traits and conditions. Recent studies have identified rare genetic variants that are likely to contribute to common diseases and traits and observed that rare variants likely to be functional, such as those in coding and regulatory regions, tend to be population-specific. PAGE II has genotyped over 50,000 samples using MEGA, an Illumina high density custom exomechip array. The MEGA data is being imputed in PAGE to the 1000 Genomes panel. PAGE also sequenced 1,000 samples representative of 21 populations from the Americas. PAGE has harmonized phenotype data for ~300 trait variables. These datasets will be analyzed to continue emphasis on characterizing population-level disease risks in non-European-descent individuals. Cohorts in PAGE II are: CALiCo (Causal Variants Across the Life Course, a consortium of ARIC, CARDIA, HCHS/SOL, Strong Heart Studies), ISMMS (Mount Sinai BioMe Biobank), MEC (Multiethnic Cohort), WHI (Women's Health Initiative), and Stanford University (PAGE Global Reference Panel). Genotyping services were provided by the Center for Inherited Disease Research (CIDR) and sequence data were provided by the McDonnell Genome Institute at Washington University School of Medicine.</p> <p>PAGE I (2008-2013): The first phase of PAGE examined putative causal genetic variants across approximately 100,000 African Americans, Asian Americans, American Indians, European Americans, Hispanic Americans, and Native Hawaiians from four groups representing nine large U.S.-based cohorts. Two genotyping approaches were employed - targeted genotyping of selected SNPs identified in genome-wide association studies of common disease, and a large-scale effort focused on the Metabochip array, which facilitated trans-ethnic fine mapping of several diseases of public health importance. Cohorts in PAGE I were: CALiCo (Causal Variants Across the Life Course, a consortium of ARIC, CARDIA, CHS, HCHS/SOL, Strong Heart Cohort Study, Strong Heart Family Study), EAGLE (Epidemiologic Architecture for Genes Linked to Environment, based on 3 National Health and Nutrition Examination Surveys (NHANES)), MEC (Multiethnic Cohort) and WHI (Women's Health Initiative).</p> <p>Logistical and scientific support is provided by the PAGE Coordinating Center and the NHGRI Division of Genomic Medicine. PAGE II is funded by the NHGRI and the NIMHD.</p> <p>To access PAGE studies currently available in dbGaP, please click on the links below.Please note that some PAGE studies belong to larger cohorts and have been included as PAGE substudies. For those studies, there is an additional link to the parent study. <ul> <li><a href="study.cgi?study_id=phs000223">phs000223</a> PAGE-ARIC and <a href="study.cgi?study_id=phs000280">phs000280</a> ARIC Cohort</li> <li><a href="study.cgi?study_id=phs000236">phs000236</a> PAGE-CARDIA and <a href="study.cgi?study_id=phs000285">phs000285</a> CARDIA Cohort</li> <li><a href="study.cgi?study_id=phs000301">phs000301</a> PAGE-CHS and <a href="study.cgi?study_id=phs000287">phs000287</a> CHS Cohort</li> <li><a href="study.cgi?study_id=phs000559">phs000559</a> PAGE-EAGLE-BioVu</li> <li><a href="study.cgi?study_id=phs000208">phs000208</a> PAGE-EAGLE-NHANES</li> <li><a href="study.cgi?study_id=phs000555">phs000555</a> PAGE-HCHS/SOL and <a href="study.cgi?study_id=phs000810">phs000810</a> HCHS/SOL Cohort</li> <li><a href="study.cgi?study_id=phs000220">phs000220</a> PAGE-MEC</li> <li><a href="study.cgi?study_id=phs000580">phs000580</a> PAGE-SHS and SHFS</li> <li><a href="study.cgi?study_id=phs001033">phs001033</a> PAGE Global Reference Panel</li> <li><a href="study.cgi?study_id=phs000227">phs000227</a> PAGE-WHI and <a href="study.cgi?study_id=phs000200">phs000200</a> WHI Cohort</li> </ul> </p>
| phs000356 | dbGaP