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Streptomyces natalensis ATCC 27448

ABSTRACT: Streptomyces natalensis ATCC 27448 Genome sequencing and assembly

PROVIDER: PRJNA176961 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	JRKI01.dat.gz	Other
	JRKI01.fasta.gz	Fasta.gz
	JRKI01.master.dat	Other
	JRKI01.dat.gz	Other

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ROS homeostasis and pimaricin production in Streptomyces natalensis ATCC 27448

Project description:The aim of this work was to unveil the molecular mechanisms by which Streptomyces respond to a ROS intracellular imbalance and the effect of such response on the biosynthesis of secondary metabolites. The study was focused on the industrial actinomycete S. natalensis ATCC 27448 producer of the polyene pimaricin - an antifungal agent widely used in the food industry and promising for antiviral activity and stimulation of immune response. Two-color microarray with common reference. The transcriptomes of S. natalensis ATCC 27448 (wild-type), S. natalensis CAM.02 (DsodF) and S. natalensis CAM.04 (DahpCD) were compared. Two time points were included: late exponential (T1) and early stationay (T2) phase. Biological triplicates were performed for each strain/time point. Genomic DNA of S. natalensis ATCC 27448 was used as common reference.

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ROS homeostasis and pimaricin production in Streptomyces natalensis ATCC 27448

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