Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Saccharomyces cerevisiae

ABSTRACT: Genome-wide Analysis of Functional Sirtuin Chromatin Targets in Yeast

PROVIDER: PRJNA177035 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR583850.fastq.gz	Fastqsanger.gz
	SRR583851.fastq.gz	Fastqsanger.gz
	SRR583852.fastq.gz	Fastqsanger.gz
	SRR583853.fastq.gz	Fastqsanger.gz
	SRR583854.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 7

Similar Datasets

Saccharomyces cerevisiae

Project description:Transcriptome-wide Analysis of Exosome Targets in the Budding Yeast Saccharomyces cerevisiae

| PRJNA172446 | ENA

Saccharomyces cerevisiae

Project description:Genome-wide targets of conserved histone chaperone Asf1 in budding yeast

| PRJNA174746 | ENA

BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae (RNA-Seq)

Project description:Human BET family members are promising targets in the therapy of cancer and immunoinflammatory diseases, but their mechanism of action and functional redundancies are poorly understood. Yeast BET factors Bdf1/2 were previously proposed to act as anchors for coactivator TFIID. We investigated their genome wide roles in transcription and found that, while they cooperate with TFIID at many genes, their contributions to transcription are often significantly different. Bdf1/2 co-occupy the majority of yeast promoters and affect preinitiation complex formation by participating in recruitment of TFIID, Mediator and basal factors to chromatin. Surprisingly, we discovered that hypersensitivity of genes to Bdf1/2 depletion results from combined defects in initiation of transcription and early elongation. Bdf1/2 are critical components of yeast transcriptional machinery with many functional similarities to human BET proteins, most notably Brd4.

2021-06-09 | GSE171065 | GEO

BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae (ChIP-Seq)

2021-06-09 | GSE171063 | GEO

BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae (ChEC-Seq)

2021-06-09 | GSE171062 | GEO

Genome-wide maps of chromatin state in saccharomyces cerevisiae

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in yeast. By obtaining bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of saccharomuces cerevisiae.We find that H3T11 phosphorylationlysine is widely distributed in gene promoter region and chromosome telomere region

2020-03-12 | GSE146821 | GEO

MNase digestion-sensitive nucleosomes in Saccharomyces cerevisiae

Project description:The structural complexity of nucleosomes underlies their functional versatility. Here we report a new type of complexity – nucleosome fragility, manifested as high sensitivity to micrococcal nuclease, in contrast to the common presumption that nucleosomes are similar in resistance to MNase digestion. Using differential MNase digestion of chromatin and high-throughput sequencing, we have identified a special group of nucleosomes termed fragile nucleosomes throughout the yeast genome, nearly one thousand of which are at previously determined “nucleosome free” loci. Nucleosome fragility is broadly implicated in multiple chromatin processes, including transcription, translocation and replication, in correspondence to specific physiological states of cells. In the environmental-stress-response genes, the presence of fragile nucleosomes prior to the occurrence of environmental changes suggests that nucleosome fragility poises genes for swift up-regulation in response to the environmental changes. We propose that nucleosome fragility underscores distinct functional statuses of the chromatin and provides a new dimension for portraying the landscape of genome organization.

2011-01-24 | GSE26412 | GEO

Genome-wide location analysis of Abf1 and Reb1 in Saccharomyces cerevisiae

Project description:Abf1 and Reb1, two general regulatory factors playing roles at promoters and other genome functional sites in budding yeast, were mapped genome-wide by ChIP-sequencing using strains expressing TAP-tagged versions of the proteins. As expected on the basis of previous in silico analysis of promoter regions, we found that these factors are enriched at the promoters of ribosome biogenesis (Ribi) genes, a large regulon of more than 200 genes required for ribosome biosynthesis and assembly, and known to be coordinately regulated in response to nutrient availability and cellular growth rate.

2017-05-04 | GSE81112 | GEO

Saccharomyces cerevisiae

Project description:Genome-wide replication analysis of a yeast eco1 mutant by deep sequencing.

| PRJNA237527 | ENA

Saccharomyces cerevisiae

Project description:Deep functional analysis of synII, a 770 kb synthetic yeast chromosome

| PRJNA352710 | ENA