Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Trichuris suis

ABSTRACT: Trichuris suis Genome sequencing and assembly

PROVIDER: PRJNA179528 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	JDFW01.dat.gz	Other
	JDFW01.fasta.gz	Fasta.gz
	JDFW01.master.dat	Other
	SRR1220949_1.fastq.gz	Fastqsanger.gz
	SRR1220949_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Trichuris suis

Project description:Trichuris suis overview

| PRJNA160343 | ENA

Trichuris suis

Project description:Transcriptome of female and male Trichuris suis

| PRJNA343717 | ENA

Trichuris suis isolate:DCEP-RM93M

Project description:Trichuris suis isolate:DCEP-RM93M Genome sequencing and assembly

| PRJNA208415 | ENA

Trichuris suis isolate:DCEP-RM93F

Project description:Trichuris suis isolate:DCEP-RM93F Genome sequencing and assembly

| PRJNA208416 | ENA

Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells

Project description:Inflammatory immune disorders such as inflammatory bowel disease (IBD) and multiple sclerosis (MS) are major health problems. Currently, the intestinal whipworm Trichuris suis is being explored in clinical trials to reduce inflammation in these diseases, however, the mechanisms by which the parasite affects the host immune system are not known. Here we determined the effects of T. suis soluble products (SPs) on toll-like receptor-4 (TLR4)-stimulated human dendritic cells (DCs) using Illumina bead chip gene arrays. Pathway analysis of lipopolysaccharide (LPS)-stimulated DCs with or without T. suis treatment showed that costimulation with T. suis SPs resulted in a down-regulation of both the myeloid differentiation primary response gene 88 (MyD88)-dependent and the TIR-domain-containing adaptor-inducing interferon-β (TRIF)-dependent signalling pathways triggered by TLR4. These data were verified using quantitative real-time PCR of several key genes within these pathways and/or defining their protein levels. In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling that interferes with its trafficking, which coincided with a reduced surface expression of TLR4. These data indicate that the mechanism by which T. suis SPs reduce inflammatory responses is through suppression of both TLR4 signalling and surface expression on DCs.

2015-05-01 | E-MTAB-3443 | biostudies-arrayexpress

Trichuris muris transcriptomics

Project description:Trichuris muris is very closely related to the human parasite T. trichiura sharing cross reactive antigens. Moreover, it is a remarkably tractable model system for dissecting immune responses and host parasite relationships and is actively being investigated in a number of laboratories worldwide. T. muris is a naturally occurring nematode parasite of mice which resides in the caecum and colon and has a direct oral faecal life cycle. High-throughput sequencing of Trichuris muris transcriptome for de novo assembly of transcripts. The main objective of this project is to recognize genes expressed in given life stages. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

2013-05-28 | E-ERAD-125 | biostudies-arrayexpress

Gene expression patterns in caecal lamina propria mononuclear cells and epithelial cells following preventive administration of T. suis ova in a rabbit model of DSS colitis

Project description:We describe the transcriptional changes occurring in lamina propria mononuclear cells (LPMC) and intestinal epithelial cells (IEC) upon Trichuris suis ova (TSO) treatment in a rabbit model of DSS colitis

2017-10-31 | GSE77372 | GEO

Preliminary study of identification of Trichuris suis by MALDI-TOF MS

Project description:Preliminary study of identification of Trichuris suis by MALDI-TOF MS

| PRJEB47832 | ENA

Mutation Mapping of 31 Streptococcus suis strains

Project description:Identification of Genes and Genomic Islands Correlated with High Pathogenicity through Tilling Microarray-Based Comparative Genomics in S. suis. Streptococcus suis is an important zoonotic pathogen that can cause meningitis and sepsis in both pigs and humans. S. suis isolates have been categorized into groups of different levels of pathogenicity, with sequence type (ST) ST1 clonal complex strains having a higher degree of virulence than other STs. However, the genetic basis of the differences in pathogenicity is still poorly understood. In this study, a comprehensive genomic comparison of 31 S. suis strains from different clinical sources with the genome sequence of the high pathogenicity (HP) strain GZ1 was conducted using NimbleGen’s tilling microarray platform.

2012-08-09 | GSE26052 | GEO

Trichuris muris

Project description:Trichuris muris overview

| PRJNA305065 | ENA