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Melilotus albus

ABSTRACT: Identifying similar transcripts in a related organism from de Bruijn graphs of RNA-Seq data, with applications to the study of salt and waterlogging tolerance in Melilotus

PROVIDER: PRJNA185437 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR8703810.fastq.gz	Fastqsanger.gz
	SRR8703811.fastq.gz	Fastqsanger.gz
	SRR8703812.fastq.gz	Fastqsanger.gz
	SRR8703813.fastq.gz	Fastqsanger.gz
	SRR8703814.fastq.gz	Fastqsanger.gz

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Genome and systems biology of Melilotus albus provides insights into coumarins biosynthesis.

Project description:Melilotus species are used as green manure and rotation crops worldwide and contain abundant pharmacologically active coumarins. However, there is a paucity of information on its genome and coumarin production and function. Here, we reported a chromosome-scale assembly of Melilotus albus genome with 1.04 Gb in eight chromosomes, containing 71.42% repetitive elements. Long terminal repeat retrotransposon bursts coincided with declining of population sizes during the Quaternary glaciation. Resequencing of 94 accessions enabled insights into genetic diversity, population structure, and introgression. Melilotus officinalis had relatively larger genetic diversity than that of M. albus. The introgression existed between M. officinalis group and M. albus group, and gene flows was from M. albus to M. officinalis. Selection sweep analysis identified candidate genes associated with flower colour and coumarin biosynthesis. Combining genomics, BSA, transcriptomics, metabolomics, and biochemistry, we identified a β-glucosidase (BGLU) gene cluster contributing to coumarin biosynthesis. MaBGLU1 function was verified by overexpression in M. albus, heterologous expression in Escherichia coli, and substrate feeding, revealing its role in scopoletin (coumarin derivative) production and showing that nonsynonymous variation drives BGLU enzyme activity divergence in Melilotus. Our work will accelerate the understanding of biologically active coumarins and their biosynthetic pathways, and contribute to genomics-enabled Melilotus breeding.

| S-EPMC8882801 | biostudies-literature

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