Human oral metagenome
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA186823 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Patients with esophageal precancerous lesions Raw sequence reads
| PRJNA777708 | ENA
Project description:Identification of microbiota in carious dentin lesions by 16S rRNA pyrosequencing
| PRJDB2587 | ENA
Project description:Gingival crevicular fluid Targeted Locus (Loci)
| PRJNA259979 | ENA
Project description:Characteristics of salivary microbiota in cancer patients
| PRJDB8324 | ENA
Project description:Oral microbiota alterations in patients with osteosarcoma
| PRJNA1016104 | ENA
Project description:Interaction between dental biofilm microbiome and gingival model
| PRJDB18360 | ENA
Project description:Characteristics of salivary microbiota in tongue cancer patients
| PRJDB10640 | ENA
Project description:Analysis of oral microbiota during sleep
| PRJDB11559 | ENA
Project description:Gut microbiome research is rapidly moving towards the functional characterization of the microbiota by means of shotgun meta-omics. Here, we selected a cohort of healthy subjects from an indigenous and monitored Sardinian population to analyze their gut microbiota using both shotgun metagenomics and shotgun metaproteomics. We found a considerable divergence between genetic potential and functional activity of the human healthy gut microbiota, in spite of a quite comparable taxonomic structure revealed by the two approaches. Investigation of inter-individual variability of taxonomic features revealed Bacteroides and Akkermansia as remarkably conserved and variable in abundance within the population, respectively. Firmicutes-driven butyrogenesis (mainly due to Faecalibacterium spp.) was shown to be the functional activity with the higher expression rate and the lower inter-individual variability in the study cohort, highlighting the key importance of the biosynthesis of this microbial by-product for the gut homeostasis. The taxon-specific contribution to functional activities and metabolic tasks was also examined, giving insights into the peculiar role of several gut microbiota members in carbohydrate metabolism (including polysaccharide degradation, glycan transport, glycolysis and short-chain fatty acid production). In conclusion, our results provide useful indications regarding the main functions actively exerted by the gut microbiota members of a healthy human cohort, and support metaproteomics as a valuable approach to investigate the functional role of the gut microbiota in health and disease.
2017-07-19 | PXD005780 | Pride