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Rattus norvegicus

ABSTRACT: Genome-wide analysis and comparison of E15 and adult rat lateral ventricular choroid plexus epithelial cells.

PROVIDER: PRJNA188518 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR672467.fastq.gz	Fastqsanger.gz
	SRR672468.fastq.gz	Fastqsanger.gz
	SRR672469.fastq.gz	Fastqsanger.gz
	SRR672470.fastq.gz	Fastqsanger.gz
	SRR672471.fastq.gz	Fastqsanger.gz

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Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach

Project description:Transcriptome analysis of lateral ventricular choroid plexus epithelial cells of embryonic day 15 (E15) and adult mice. We analyzed total RNA extracted from plexus epithelial cells from 6 pooled samples (3 E15, 3 adult) using the Affymetrix Mouse Exon 1.0 ST platform.

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Genome-wide analysis and comparison of E15 and adult rat lateral ventricular choroid plexus epithelial cells.

Project description:Transcriptome analysis of lateral ventricular choroid plexus epithelial cells of embryonic day 15 (E15) and adult control Sprague-Dawley rats. We analyzed total RNA extracted from plexus epithelial cells from 6 pooled samples (3 E15, 3 adult) using the Illumina HiSeq 2000 platform.

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Genome-wide analysis and comparison of E15 and adult rat lateral ventricular choroid plexus epithelial cells.

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Project description:The choroid plexus produces cerebrospinal fluid (CSF) by transport of electrolytes and water from the vasculature to the brain ventricles. The choroid plexus plays additional roles in brain development and homeostasis by secreting neurotrophic molecules, and by serving as a CSF-blood barrier and immune interface. Prior studies have identified transporters on the epithelial cells that transport water and ions into the ventricles and tight junctions involved in the CSF-blood barrier. Yet, how the choroid plexus epithelial cells maintain the brain ventricle system and control brain physiology remain unresolved. To provide novel insights into the physiological roles of the choroid plexus, we use juvenile and adult zebrafish as model systems. Upon histological and transcriptomic analyses, we first identified that the zebrafish choroid plexus is highly conserved with the mammalian choroid plexus and that it expresses all transporters necessary for CSF secretion. Using novel genetic lines, we also identified that the choroid plexus secretes proteins into the CSF. Next, we generated a transgenic line allowing us to ablate specifically the epithelial cells in the choroid plexus. Using the ablation system, we identified a reduction of the ventricular sizes, but no alterations of the CSF-blood barrier. Altogether, our findings identified that the zebrafish choroid plexus is evolutionarily conserved and critical for maintaining the size and homeostasis of the brain ventricles.

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