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Mus musculus

ABSTRACT: An Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (RNA-Seq)

PROVIDER: PRJNA190912 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR765631_1.fastq.gz	Fastqsanger.gz
	SRR765631_2.fastq.gz	Fastqsanger.gz
	SRR765632_1.fastq.gz	Fastqsanger.gz
	SRR765632_2.fastq.gz	Fastqsanger.gz
	SRR765633_1.fastq.gz	Fastqsanger.gz

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Project description:An Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes

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An Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (ChIP-Seq)

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An Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (RNA-Seq)

Project description:Animal germ cells produce PIWI-interacting RNAs (piRNAs), small silencing RNAs that suppress transposons and enable gamete maturation. Mammalian transposon-silencing piRNAs accumulate early in spermatogenesis, whereas pachytene piRNAs are produced later during post-natal spermatogenesis and account for >95% of all piRNAs in the adult mouse testis. Mutants defective for pachytene piRNA pathway proteins fail to produce mature sperm, but neither the piRNA precursor transcripts nor the trigger for pachytene piRNA production is known. Here, we show that the transcription factor A-MYB initiates pachytene piRNA production. A-MYB drives transcription of both pachytene piRNA precursor RNAs and the mRNAs for core piRNA biogenesis factors, including MIWI, the protein through which pachytene piRNAs function. A-MYB regulation of piRNA pathway proteins and piRNA genes creates a coherent feed-forward loop that ensures the robust accumulation of pachytene piRNAs. This regulatory circuit, which can be detected in rooster testes, likely predates the divergence of birds and mammals. Transcriptome and ChIP sequencing in mouse and rooster testes

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2013-03-26 | E-GEOD-44588 | biostudies-arrayexpress

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Mus musculus

Project description:An Ancient Transcription Factor An Ancient Transcription Factor During Early Meiosis in Mouse Testes (PAS-Seq and CAGE)

| PRJNA194539 | ENA

An Ancient Transcription Factor Initiates the Burst of piRNA Production During Early Meiosis in Mouse Testes (smallRNA-Seq)

2013-03-27 | GSE45049 | GEO