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Mus musculus

ABSTRACT: The interactome of Pou5f1 enhancer in mouse embryonic stem cells

PROVIDER: PRJNA193670 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR790975.fastq.gz	Fastqsanger.gz
	SRR790976.fastq.gz	Fastqsanger.gz

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Mus musculus

Project description:The interactome of POU5F1 upstream enhancer in mouse embryonic stem cells revealed by 4C-Seq

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The interactome of Pou5f1 enhancer in mouse embryonic stem cells

Project description:We report the application of enyzme-based 4C-Seq technique for exploring Pou5f1 enhancer interactome in mouse ES cells. We explored the interactome of Pou5f1 upstream enhancer in mouse ES cells by using an enzyme digestion based 4C-Seq protocol. The interactome is involved in gene active regulation.

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Project description:We report the application of 4C-Seq technique for exploring POU5F1 enhancer interactome in mouse embryonic stem cells. A statistical model was built to identify enriched interacting regions from raw 4C data. The biological replicate data were compared to identify reproducible interacting regions. The interacting sites in the reproducible regions are enriched with active histone marks as well as transcription factors Oct4, Klf4, Esrrb, Tcfcp2i1 and Zfx that are critical for reprogramming and pluripotency. Generation of Illumina HiSeq2000 sequencing data using 4C-Seq protocol

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