Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Arabidopsis thaliana

ABSTRACT: MethlyC-Seq of ibm1-4

PROVIDER: PRJNA208792 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR907553_1.fastq.gz	Fastqsanger.gz
	SRR907553_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Arabidopsis thaliana

Project description:MethlyC-Seq of met18 mutant

| PRJNA271804 | ENA

Arabidopsis thaliana

Project description:MethlyC-Seq of ros1-13 mutant

| PRJNA253486 | ENA

Arabidopsis thaliana

Project description:MethlyC-Seq of Col-0 background wild-type (WT)

| PRJNA230705 | ENA

Genome-wide analysis of H3K9me2 in ibm1, kyp, and cmt3 mutants of Arabidopsis thaliana

Project description:In diverse eukaryotes, constitutively silent sequences, such as transposons and repeats, are marked by methylation at histone H3 lysine 9 (H3K9me). Despites the conservation and importance in the genome integrity, mechanisms to exclude H3K9m from active genes remained largely unexplored. Here we show in Arabidopsis that the exclusion depends on a histone demethylase gene, IBM1 (increase in BONSAI methylation); loss-of-function ibm1 mutation caused ectopic H3K9me in thousands of genes, which accompanies genic DNA methylation at non-CG sites. The ibm1-induced genic H3K9me depended on both histone methylase KYP/SUVH4 and DNA methylase CMT3, suggesting interdependence of two epigenetic marks – H3K9me and non-CG methylation. Notably, IBM1 enhanced loss of H3K9m in transcriptionally de-repressed sequences. Furthermore, disruption of transcription in genes induced ectopic non-CG methylation, mimicking the loss of IBM1 function. We propose that active chromatin is stabilized by the autocatalytic loop of transcription and H3K9 demethylation. This process counteracts accumulation of silent epigenetic marks, H3K9me and non-CG methylation, which is also autocatalytic.

2010-09-21 | GSE22953 | GEO

Arabidopsis thaliana

Project description:MethlyC-Seq of nrpd1-3, nrpd1-12, and nrpe1-11

| PRJNA271134 | ENA

Arabidopsis thaliana

Project description:mRNA-Seq of asi1-1, wild-type and MethlyC-Seq of asi1-1

| PRJNA208726 | ENA

Arabidopsis thaliana

Project description:MethlyC-Seq of Col-0 WT and mbd7-2(CS876032) mutant

| PRJNA253488 | ENA

Arabidopsis thaliana

Project description:MethlyC-Seq of met18-1(SALK_121963) and met18-2(SALK_147068) mutant