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Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 2)

ABSTRACT: Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 2)

PROVIDER: PRJNA218869 | ENA |

REPOSITORIES: ENA

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Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

Project description:Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

| PRJNA218868 | ENA

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

Project description:Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

| PRJNA218867 | ENA

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 2)

Project description:To better characterize how variation in regulatory sequences drives divergence in gene expression, we undertook a systematic study of transcription factor binding and gene expression in blastoderm embryos of four species, which sample much of the diversity in the 40 million-year old genus Drosophila: D. melanogaster, D. yakuba, D. pseudoobscura and D. virilis. We compared gene expression, measured by mRNA-seq, to the genome-wide binding, measured by ChIP-seq, of four transcription factors involved in early anterior-posterior patterning. We found that mRNA levels are much better conserved than individual transcription factor binding events, and that changes in a gene’s expression were poorly explained by changes in adjacent transcription factor binding. However highly bound sites, sites in regions bound by multiple factors and sites near genes are conserved more frequently than other binding, suggesting that a considerable amount of transcription factor binding is weakly or non-functional and not subject to purifying selection

2013-09-12 | GSE50771 | GEO

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

Project description:We sequenced mRNA from blastoderm embryos of Drosophila melanogaster, Drosophila yakuba, Drosophila pseudoobscura and Drosophila virilis. Two samples contain pooled mRNA from several species, and the remaining 24 samples contain mRNA from a single species. Methods: Retinal mRNA profiles of Blastoderm embryos

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Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

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Extensive functional divergence of the RosR transcription factor across haloarchaea

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Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression.

Project description:To better characterize how variation in regulatory sequences drives divergence in gene expression, we undertook a systematic study of transcription factor binding and gene expression in blastoderm embryos of four species, which sample much of the diversity in the 40 million-year old genus Drosophila: D. melanogaster, D. yakuba, D. pseudoobscura and D. virilis. We compared gene expression, measured by mRNA-seq, to the genome-wide binding, measured by ChIP-seq, of four transcription factors involved in early anterior-posterior patterning. We found that mRNA levels are much better conserved than individual transcription factor binding events, and that changes in a gene's expression were poorly explained by changes in adjacent transcription factor binding. However, highly bound sites, sites in regions bound by multiple factors and sites near genes are conserved more frequently than other binding, suggesting that a considerable amount of transcription factor binding is weakly or non-functional and not subject to purifying selection.

| S-EPMC3772039 | biostudies-literature

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Regulatory divergence during mouse limb evolution

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