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Shigella flexneri 2a str. 2457T

ABSTRACT: Identification of transcriptional pathways associated with enviromental modification

PROVIDER: PRJNA237637 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR1185101_1.fastq.gz	Fastqsanger.gz
	SRR1185101_2.fastq.gz	Fastqsanger.gz
	SRR1185291_1.fastq.gz	Fastqsanger.gz
	SRR1185291_2.fastq.gz	Fastqsanger.gz
	SRR1185302_1.fastq.gz	Fastqsanger.gz

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Project description:Shigella flexneri 2a str. 2457T Raw sequence reads

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Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T.

Project description:We determined the complete genome sequence of Shigella flexneri serotype 2a strain 2457T (4,599,354 bp). Shigella species cause >1 million deaths per year from dysentery and diarrhea and have a lifestyle that is markedly different from those of closely related bacteria, including Escherichia coli. The genome exhibits the backbone and island mosaic structure of E. coli pathogens, albeit with much less horizontally transferred DNA and lacking 357 genes present in E. coli. The strain is distinctive in its large complement of insertion sequences, with several genomic rearrangements mediated by insertion sequences, 12 cryptic prophages, 372 pseudogenes, and 195 S. flexneri-specific genes. The 2457T genome was also compared with that of a recently sequenced S. flexneri 2a strain, 301. Our data are consistent with Shigella being phylogenetically indistinguishable from E. coli. The S. flexneri-specific regions contain many genes that could encode proteins with roles in virulence. Analysis of these will reveal the genetic basis for aspects of this pathogenic organism's distinctive lifestyle that have yet to be explained.

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Genome-wide reconstruction of the bacterial response to single and multiple stress in Shigella flexneri 2a str. 2457T

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-12-22 | GSE173348 | GEO

Genome-wide reconstruction of the bacterial response to single and multiple stress in Shigella flexneri 2a str. 2457T (S. flexneri RNA-Seq)

Project description:The genome-wide analysis was carried out to find out the genes responsible for single and multiple stress in Shigella flexneri 2a str. 2457T. This result can be offered to explain bacterial responses, such as the capacity to survive and elicit infections.

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