Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Escherichia coli O127:H6 str. E2348/69

ABSTRACT: Identification of transcriptional pathways associated with enviromental modification

PROVIDER: PRJNA237642 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1182844_1.fastq.gz	Fastqsanger.gz
	SRR1182844_2.fastq.gz	Fastqsanger.gz
	SRR1182845_1.fastq.gz	Fastqsanger.gz
	SRR1182845_2.fastq.gz	Fastqsanger.gz
	SRR1182808_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69.

Project description:Enteropathogenic Escherichia coli (EPEC) was the first pathovar of E. coli to be implicated in human disease; however, no EPEC strain has been fully sequenced until now. Strain E2348/69 (serotype O127:H6 belonging to E. coli phylogroup B2) has been used worldwide as a prototype strain to study EPEC biology, genetics, and virulence. Studies of E2348/69 led to the discovery of the locus of enterocyte effacement-encoded type III secretion system (T3SS) and its cognate effectors, which play a vital role in attaching and effacing lesion formation on gut epithelial cells. In this study, we determined the complete genomic sequence of E2348/69 and performed genomic comparisons with other important E. coli strains. We identified 424 E2348/69-specific genes, most of which are carried on mobile genetic elements, and a number of genetic traits specifically conserved in phylogroup B2 strains irrespective of their pathotypes, including the absence of the ETT2-related T3SS, which is present in E. coli strains belonging to all other phylogroups. The genome analysis revealed the entire gene repertoire related to E2348/69 virulence. Interestingly, E2348/69 contains only 21 intact T3SS effector genes, all of which are carried on prophages and integrative elements, compared to over 50 effector genes in enterohemorrhagic E. coli O157. As E2348/69 is the most-studied pathogenic E. coli strain, this study provides a genomic context for the vast amount of existing experimental data. The unexpected simplicity of the E2348/69 T3SS provides the first opportunity to fully dissect the entire virulence strategy of attaching and effacing pathogens in the genomic context.

| S-EPMC2612414 | biostudies-literature

Escherichia coli O127:H6 str. E2348/69

Project description:Enteropathogenic strain

| PRJEA32571 | ENA

Escherichia coli O127:H6 str. E2348/69

Project description:Comparative genomics provides insight into the diversity of the attaching and effacing Escherichia coli (AEEC) virulence plasmids

| PRJNA285331 | ENA

Shigella flexneri 2a str. 2457T

Project description:Identification of transcriptional pathways associated with enviromental modification

| PRJNA237637 | ENA

Escherichia coli O139:H28 str. E24377A

Project description:Identification of transcriptional pathways associated with enviromental modification

| PRJNA237643 | ENA

Escherichia coli O127:H6 str. E2348/69 substr. CVDNalr

Project description:Escherichia coli O127:H6 str. E2348/69 substr. CVDNalr Genome sequencing and assembly

| PRJNA204931 | ENA

Escherichia coli O127:H6 str. E2348/69 substr. UMD753

Project description:Escherichia coli O127:H6 str. E2348/69 substr. UMD753 Genome sequencing and assembly

| PRJNA204937 | ENA

Escherichia coli 100329

Project description:Identification of transcriptional pathways associated with enviromental modification

| PRJNA237625 | ENA

Escherichia coli HS strain:HS

Project description:Identification of transcriptional pathways associated with enviromental modification

| PRJNA237645 | ENA

Escherichia coli BCE032

Project description:Identification of transcriptional pathways associated with enviromental modification

| PRJNA237640 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data