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Clostridium sporogenes strain:DSM 795

ABSTRACT: Clostridium sporogenes strain:DSM 795 Genome sequencing and assembly

PROVIDER: PRJNA239205 | ENA |

REPOSITORIES: ENA

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Clostridium sporogenes strain:DSM 795

Project description:Clostridium sporogenes DSM 795 Genome sequencing

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Clostridium sporogenes-derived metabolites protect against colonic inflammation

Project description:Purpose: Gut microbiota-derived metabolites play a pivotal role in the maintenance of local gut homeostasis and can even induce systemic effects via accumulation in the bloodstream. Here, we demonstrate that mono-colonization of germ-free (GF) mice with Clostridium sporogenes protects mice from inflamation and death induced by DSS colitis. Method: 8-12-week-old male mice (GF, SPF and GF colonized with C. sporogenes (CS)) were treated with 2.5% DSS in drinking water for 5 days and colon tissue was isolated on day 7. RNA was isolated from the colon tissue and RNA sequenzing was performed. Results: Mono-colonization of GF mice with Clostridium sporogenes protected the mice from DSS colitis induced death, while producing high amounts of indole-3-propionic acid (IPA), branched chain (BCFA) and short-chain (SCFA) fatty acids. In comparison to CS mice, SPF mice showed much higher levels of inflammatory related genes and a worse histological score. Conclusion: Histological stainings and the RNAseq both showed high levels of protection of C. sporogenes colonized mice in colitis, compared to SPF and GF animals. The data provide evidence for a therapeutic potential of C. sporogenes for IBD patients.

2024-10-15 | GSE264024 | GEO

Comparative genomic hybridization of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes

Project description:Genomic DNA of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes was subjected to analysis by DNA microarray.

2008-12-31 | E-MEXP-1637 | biostudies-arrayexpress

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Project description:Clostridium sporogenes Genome sequencing and assembly

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Clostridium sporogenes strain:4992

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Clostridium sporogenes strain:4990

Project description:Clostridium sporogenes strain:4990 Genome sequencing and assembly

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Array-based transcriptional analysis of Clostridium sporogenes during germination, cell outgrowth and vegetative life

Project description:The members of the genus Clostridium, such as the other spore-forming anaerobic bacteria, have a complex and strictly regulated life-cycle but very little is known about genetic pathways involved at different stages. Clostridium sporogenes, Gram positive bacterium usually involved in food spoilage and frequently isolated from late blowed cheese is genetically indistinguishable from proteolytic Clostridium botulinum and is the non-neurotoxigenic counterpart often used as exemplar for the toxic subtypes. In this work we have performed a microscopy study combined with a custom array-based analysis of C. sporogenes cycle, from dormant spores to early stationary phase. We identified in spores a total of 211 transcripts validating the ipothesis that mRNAs are abundant and strikingly different from those present in growing cells. The spores transcripts included genes responsible of different life-sustaining functions, suggesting the theory of transcripts entrapment or of a basic poly-functional genes activation for future steps. In addition, after three hours from the beginning of the germination process, a 20% of the total up-regulated genes were temporally expressed in germinating spores. The vegetative condition appears to be the more active in terms of gene transcription and protein synthesis and also genes for germination and sporulation factors seem to be expressed at this point. These results suggest that spores are not silent entities and a wider knowledge about genetic pathways involved in Clostridium life cycle could be of help for a better understanding also of pathogenic clostridia types.

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Clostridium sporogenes strain:AFW

Project description:Clostridium sporogenes strain:AFW Genome sequencing

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