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Aspergillus fumigatus

ABSTRACT: Next Generation Sequencing identifies O2-responsive genes in the human pathogenic fungus Aspergillus fumigatus

PROVIDER: PRJNA241401 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1197140.fastq.gz	Fastqsanger.gz
	SRR1197141.fastq.gz	Fastqsanger.gz
	SRR1197142.fastq.gz	Fastqsanger.gz
	SRR1197143.fastq.gz	Fastqsanger.gz
	SRR1197144.fastq.gz	Fastqsanger.gz

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Effect of Artemisinin on Aspergillus fumigatus gene expression program

Project description:We examined the antifungal activity of artemisinin against Aspergillus fumigatus (A. fumigatus), a pathogenic filamentous fungus responsible for allergic and invasive aspergillosis in humans and analyzed transcript profiles of the fungus on exposure to Artemisinin. A. fumigatus spores were cultured for 48 h and then treated with artemisinin (at MIC50 concentration) or solvent control (DMSO) for 3 h to study its transcriptomic profiles.

2011-05-11 | GSE21297 | GEO

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Project description:We report a study conducted to investigate the variation on gene expression of the pathogenic fungus Aspergillus fumigatus upon co-cultivation with the pathogenic bacterium Pseudomonas aeruginosa. The study was conducted by investigating the gene expression variation at different time points (45, 90 and 180 minutes after co-incubation). As control, we used data obtained by cultivating the fungus either without bacteria, or with heat-inactivated Pseudomonas.

2018-12-09 | GSE122391 | GEO

Triple-Sequencing of dendritic cells coinfected with Aspergillus fumigatus and cytomegalovirus

Project description:Human dendritic cells were coinfected with Aspergillus fumigatus and human cytomegalovirus. Single-cultures or single-infections served as controls. RNA was isolated and processed for next generation sequencing.

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Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

Project description:The transcription factor CrzA influences cell wall organization in the pathogenic fungus Aspergillus fumigatus, and also binds to the promoter regions of chitin synthase genes upon exposure to the antifungal drug caspofungin. To gain an overview of the genes directly regulated by CrzA, the CrzA binding sites were determined genome-wide by ChIP-seq

2021-08-02 | GSE179132 | GEO

Transcriptome response of Aspergillus fumigatus cultures under different temperatures

Project description:Microarray analysis was used to compare gene expression of Aspergillus fumigatus under two different sporulation temperatures, 17oC and 32oC, with an emphasis on genes encoding known or putative allergens of the fungus. The objective of the study was to investigate whether allergenic potencies of A. fumigatus spores produced under different sporulation temperatures would be influenced by temperature-dependent transcriptional regulation of allergenicity genes.

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Temporal dynamics of human cells co-cultivated with Aspergillus fumigatus

Project description:This SuperSeries is composed of the following subset Series: GSE21353: Gene expression profiles of human immature dendritic cells after 3h, 6h and 12h of co-cultivation with Aspergillus fumigatus GSE28806: The temporal dynamics of differential gene expression in human alveolar epithelial and endothelial cells interacting with the human pathogenic mould Aspergillus fumigatus in vitro Refer to individual Series

2012-04-16 | E-GEOD-28809 | biostudies-arrayexpress

Aspergillus fumigatus transcriptome under normoxia and hypoxia conditions

Project description:To better understand the effect of hypoxia, RNA-Seq technology was used to profile the Aspergillus fumigatus during adaptation to hypoxia at 12, 24 and 36 h time points. Four samples examined: from the fungus grown under normoxia and hypoxia conditions

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Project description:The infections with the human pathogenic fungus A. fumigatus is an emerging problem. The infections process and the reaction of the immune systeme to the infection is still not complete understood. So we analyzed the response of A. fumigatus to human neutrophils to get insights of these interaction.

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