Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Next Generation Sequencing identifying the dosage compensation state in human endometrial carcinoma and adjacent tissues

OTHER RELATED OMICS DATASETS IN: E-GEOD-56087

PROVIDER: PRJNA242387 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1200850_1.fastq.gz	Fastqsanger.gz
	SRR1200850_2.fastq.gz	Fastqsanger.gz
	SRR1200860_1.fastq.gz	Fastqsanger.gz
	SRR1200860_2.fastq.gz	Fastqsanger.gz
	SRR1200870_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

E-GEOD-56087

Project description:Next Generation Sequencing identifying the dosage compensation state in human endometrial carcinoma and adjacent tissues

2025-01-24 | E-GEOD-56087 | ExpressionAtlas

E-GEOD-83322

Project description:Next Generation Sequencing of liver and subcutaneous fat tissues obtained from obese subjects

2025-01-21 | E-GEOD-83322 | ExpressionAtlas

Next Generation Sequencing identifying the dosage compensation state in human endometrial carcinoma and adjacent tissues

Project description:Mammals have evolved an XY sex chromosome system, resulting in dosage imbalance not only between sexes, but also between X-chromosome and autosome. mRNA profiles of 9 pairs of human endometrial carcinoma and adjacent tissues were generated by Illumina 100-nucleotide paired-end sequencing

2015-01-07 | E-GEOD-56087 | biostudies-arrayexpress

E-GEOD-65485

Project description:Next Generation Sequencing Identification of HBV-MLL4 integration and its molecular basis in Chinese hepatocellular carcinoma

2025-01-24 | E-GEOD-65485 | ExpressionAtlas

Next Generation Sequencing from Tumor Tissues And Tumor-adjacent Tissues of Renal Cell Carcinoma

Project description:Next Generation Sequencing from Tumor Tissues And Tumor-adjacent Tissues of Renal Cell Carcinoma

| PRJNA808984 | ENA

E-GEOD-69556

Project description:Next Generation Sequencing of PKD2 mutant mice kidneys

2019-05-14 | E-GEOD-69556 | ExpressionAtlas

E-GEOD-50424

Project description:Characterization of genome-wide transcriptional changes in liver and adipose tissues of ZDF (fa/fa) rats fed R--lipoic acid by next-generation sequencing

2019-05-14 | E-GEOD-50424 | ExpressionAtlas

E-GEOD-60424

Project description:Next generation sequencing of human immune cell subsets across diseases

2025-01-24 | E-GEOD-60424 | ExpressionAtlas

RNA stability controlled by m6A methylation provides X to autosome compensation in mammals [RNA-seq]

Project description:In therian mammals, X-chromosomal genes are expressed only from a single active X chromosome, both in males (XY) as well as females (XX). To compensate for this reduction in dosage compared to the evolutionary ancestral state on two autosomes, it has been proposed that genes from the active X chromosome exhibit dosage compensation (“Ohno’s hypothesis”). However, the existence and mechanism of X-to-autosome dosage compensation are still under debate. Here, we show that dosage compensation is achieved via differential N6-methyladenosine (m6A) RNA modification. X-chromosomal transcripts are reduced in m6A modifications and more stable compared to the autosomal counterparts. Acute depletion of m6A using a small molecule inhibitor differentially affects autosomal and X-chromosomal transcripts across sexes, cell types, tissues and species, resulting in perturbed dosage compensation. We propose that higher stability of X-chromosomal transcripts is directed by lower levels of m6A, indicating that mammalian dosage compensation occurs via epitranscriptomic RNA regulation.

2023-02-14 | GSE203642 | GEO