Project description:Genome-wide assessment of gene expression in primary acute lymphoblastic leukemia cells was performed to identify genomic determinants of MTXâs antileukemic effects. Reduction of circulating leukemia cells after in vivo methotrexate treatment served as a measure MTX's antileukemic effects. Experiment Overall Design: Gene expression in diagnostic primary acute lymphoblastic leukemia cells from bone marrow of 161 pediatric patients
Project description:RNA was extracted from the diagnostic bone marrow specimens of 50 T-cell acute lymphoblastic leukemia pediatric patients and analysed by Affymetrix microarray to model gene classifiers predictive of clinical outcome
