Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus

ABSTRACT: Suv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells

PROVIDER: PRJNA245416 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR1262950_1.fastq.gz	Fastqsanger.gz
	SRR1262950_2.fastq.gz	Fastqsanger.gz
	SRR1262960_1.fastq.gz	Fastqsanger.gz
	SRR1262960_2.fastq.gz	Fastqsanger.gz
	SRR1262970_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 78

Similar Datasets

Suv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells

Project description:Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP-sequencing in mouse embryonic stem cells (ESCs). Refined bioinformatic analyses of repeat subfamilies indicated selective accumulation of Suv39h-dependent H3K9me3 at interspersed repetitive elements that cover ~ 5% of the ESC epigenome. The majority of the ~ 8,150 intact long interspersed nuclear elements (LINEs) and endogenous retroviruses (ERVs), but only a minor fraction of the > 1.8 million degenerate and truncated LINEs/ERVs, are enriched for Suv39h-dependent H3K9me3. Transcriptional repression of these intact LINEs and ERVs is differentially regulated by Suv39h and other chromatin modifiers in ESCs but governed by DNA methylation in committed cells. These data provide a novel function for Suv39h-dependent H3K9me3 chromatin to specifically repress intact retrotransposon elements in the ESC epigenome. ChIP-seq and RNA-seq in mouse ES cells, Neural precursors and MEFs wild type and Suv39h double KO. The input for ES cells is accessioned as GSM1251941. A link to this sample can be found below.

2014-06-26 | E-GEOD-57092 | biostudies-arrayexpress

Suv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells

2014-06-26 | GSE57092 | GEO

E-MTAB-7655

Project description:RNA-Seq of Sall4 mutants in mouse embryonic stem cells

2019-09-09 | E-MTAB-7655 | ExpressionAtlas

E-MTAB-5189

Project description:Transcriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells

2019-05-14 | E-MTAB-5189 | ExpressionAtlas

E-GEOD-46730

Project description:Transcriptome Analysis of LincRNA TUNA Knockdown in Mouse Embryonic Stem Cells

2019-05-14 | E-GEOD-46730 | ExpressionAtlas

E-TABM-673

Project description:Transcription profiling by array of mouse embryonic stem cells cultured with LY294002

2014-07-03 | E-TABM-673 | ExpressionAtlas

E-TABM-669

Project description:Transcription profiling of mouse embryonic stem cell line Sox1Tv2 during neuronal differentiation

2015-11-02 | E-TABM-669 | ExpressionAtlas

E-GEOD-27843

Project description:Transcription profiling by high throughput sequencing of mouse embryonic fibroblasts, terminally differentiated neurons and embryonic stem cells

2016-05-13 | E-GEOD-27843 | ExpressionAtlas

E-TABM-89

Project description:Transcription profiling by array of mouse embryonic stem cells after treatment with cisplatin

2015-11-02 | E-TABM-89 | ExpressionAtlas

E-MTAB-7343

Project description:RNA-Seq of mouse embryonic stem cells in response to changes in Sall4

2020-07-15 | E-MTAB-7343 | ExpressionAtlas