Project description:We optimized the SHAPE-MaP (selective 2'-hydroxyl acylation analyzed by primer extension and mutational profiling) assay to analyze structures of paired circular (circSHAPE-MaP) and linear (linearSHAPE-MaP) RNAs.
Project description:Mutational Interference Mapping Experiment (MIME) to identify the binding site of the HIV-1 Pr55Gag protein to the HIV-1 genomic RNA