Project description:There were no studies about gene expression of normal gingiva before. We performed this study to compare with gene expression of gingival fibromatosis
Project description:All experiment was done according to the Affymetrix manufacturer’s protocol. The resulting HGF gingiva expression profile(Hereditary gingival fibromatosis patient Gingiva replicate1 and replicate 2)was compared to normal gingiva control(Normal Gingiva replicate1 and replicate2). The data were collected and analyzed by GCOS 1.2 and GeneSpring 7.2 1-way T test. Keywords: tissue specific expression profile
Project description:All experiment was done according to the Affymetrix manufacturerâs protocol. The resulting HGF gingiva expression profile(Hereditary gingival fibromatosis patient Gingiva replicate1 and replicate 2)was compared to normal gingiva control(Normal Gingiva replicate1 and replicate2). The data were collected and analyzed by GCOS 1.2 and GeneSpring 7.2 1-way T test. Experiment Overall Design: Hereditary gingival fibromatosis patient Gingiva (experimental) and Normal Gingiva (control) were used. N1 and P1 are gingiva tissue from female individuals while N2 and P2 are from male ones.
Project description:Gingival fibromatosis (GF) is a rare oral condition characterized by proliferative fibrous overgrowth of both the attached and marginal gingiva, and the interdental papilla. But there were no papers about gene expression of gingival fibromatosis. The aim of this study was to identify the differential expression of genes in GF using cDNA microarray analysis.
Project description:This study is the first to report on the transcriptome of healing gingiva and to provide an integrative analysis of mRNA/miRNA expression during human oral wound healing; the results offer novel insights into the participating molecular mechanisms and suggest that miR-124-3p and PXDN could be potential wound healing therapeutic targets.
Project description:This study is the first to report on the miRNome of healing gingiva and to provide an integrative analysis of mRNA/miRNA expression during human oral wound healing; the results offer novel insights into the participating molecular mechanisms and suggest that miR-124-3p and PXDN could be potential wound healing therapeutic targets.