Project description:The genome wide DNA copy number profiles of the biphasic epithelioid (E-) and sarcomatoid (S-) components of sarcomatoid clear cell renal cell carcinoma were analyzed using SNP arrays. The E- and S- components showed a similar DNA copy number profile, despite morphologic differences.
Project description:Two subsets of early genetic mutations closely related to the malignant behavior of renal sarcomatoid carcinoma were identified by exon sequencing, transcriptome sequencing, protein profiling and clonal evolution of self-established renal sarcomatoid carcinoma cell lines and subclones of different secretion states
