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Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans

ABSTRACT: Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans

PROVIDER: PRJNA257516 | ENA |

REPOSITORIES: ENA

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Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans [CGH]

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Mistranslation accelerates the adaptation of Candida albicans to Fluconazole

Project description:The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the presence and absence of the antifungal drug fluconazole. Elevated levels of mistranslation resulted in the rapid acquisition of resistance to fluconazole.

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Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans

Project description:This SuperSeries is composed of the SubSeries listed below.

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