Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Escherichia coli K1 strain:926

ABSTRACT: Escherichia coli K1 strain:926 Genome sequencing

PROVIDER: PRJNA257956 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	JQFR01.dat.gz	Other
	JQFR01.fasta.gz	Fasta.gz
	JQFR01.master.dat	Other
	JQFR01.dat.gz	Other

Items per page:

1 - 4 of 4

Similar Datasets

Escherichia coli strain:926 | isolate:926

Project description:Escherichia coli strain:926 | isolate:926 Genome sequencing

| PRJNA977436 | ENA

In vitro and in vivo preclinical characterization of a preconceptionally administered maternal vaccine against severe neonatal Escherichia coli K1 infections

Project description:Preterm birth is currently the leading cause of neonatal morbidity and mortality. Genetic, immunological and infectious causes are suspected. Preterm infants have a higher risk of severe bacterial neonatal infections, most of which are caused by Escherichia coli an in particular E. coli K1strains. Women with history of preterm delivery have a high risk of recurrence and therefore constitute a target population for the development of vaccine against E. coli neonatal infections. Here, we characterized the immunological, microbiological and protective properties of a live attenuated vaccine candidate in adult female mice and their pups against after a challenge by K1 and non-K1 strains of E. coli. Our results show that the E. coli K1 E11 aroA vaccine induces strong immunity, driven by polyclonal bactericidal antibodies. In our model of meningitis, pups born to mothers immunized before mating were well protected against various K1 and non-K1 strains of E. coli. Given the very high mortality rate and the neurological sequalae associated with neonatal E. coli K1 meningitis, our results constitute preclinical proof of concept for the development of a live attenuated vaccine against severe E. coli infections in women at risk of preterm delivery.

2024-01-02 | GSE252194 | GEO

Escherichia coli K1 strain:949

Project description:Escherichia coli K1 strain:949 Genome sequencing

| PRJNA257977 | ENA

Escherichia coli K1 strain:910

Project description:Escherichia coli K1 strain:910 Genome sequencing

| PRJNA257953 | ENA

Escherichia coli K1 strain:913

Project description:Escherichia coli K1 strain:913 Genome sequencing

| PRJNA257954 | ENA

Escherichia coli K1 strain:934

Project description:Escherichia coli K1 strain:934 Genome sequencing