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Aspergillus fumigatus strain:CEA10

ABSTRACT: Gene expression in Aspergillus fumigatus hexadehydroastechrome production mutants (non-ribosomal peptide)

PROVIDER: PRJNA258513 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1614170_1.fastq.gz	Fastqsanger.gz
	SRR1614170_2.fastq.gz	Fastqsanger.gz
	SRR1614171_1.fastq.gz	Fastqsanger.gz
	SRR1614171_2.fastq.gz	Fastqsanger.gz
	SRR1614172_1.fastq.gz	Fastqsanger.gz

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Aspergillus fumigatus strain:CEA10

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Project description:Aspergillus fumigatus is a ubiquitous mould but also an opportunistic human pathogen causing life-threatening infections in immunocompromised patients. Survival of the fungus in different habitats depends on effective mechanisms of signal perception and transduction such as the cAMP dependent protein kinase A (PKA) pathway, which is involved in virulence of A. fumigatus. Here, by transcriptome analysis putative targets of this important signaling cascade were identified, revealing 632 differently regulated genes including 23 putative transcriptional regulators. The highest up-regulated transcription factor gene was located in the until now unknown fmp secondary metabolite gene cluster encoding an incomplete non-ribosomal peptide synthetase as core enzyme. Overexpression of the fmp cluster resulted in formation of fumipyrrole, which was not described as natural product yet. Although genes of the fmp cluster are transcribed in infected mouse lungs, deletion of its regulatory gene fmpR resulted in wild-type virulence in a murine infection model.

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